KH-259
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
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- CAS No.: 3023019-93-1
- Formule: C20H25N3O2
- Masse moléculaire:339.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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HDAC6 0.26 ± 0.2 μM (IC50) |
HDAC1 6.7 ± 0.14 μM (IC50) |
HDAC4 12.3 ± 0.4 μM (IC50) |
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3023019-93-1
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Masse moléculaire 339.43
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Formule C20H25N3O2
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SMILES
CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KH-259 Related Classifications
HY-150503 Related Classifications
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