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Cat. No.: HY-116330

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Hyperforin

Name: Hyperforin
Brand: MedChemExpress
SKU: HY-116330
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3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

For research use only. We do not sell to patients.

CAS No.: 11079-53-1
Formula: C₃₅H₅₂O₄
Molecular Weight:536.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Hyperforin Chemical Structure

CAS No.: 11079-53-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TRPC6^[1]

All Calcium Channel Isoforms :

All TRP Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 1	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25871261]
HL-60	IC₅₀	>40 μM Compound: 1	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25871261]
MCF7	IC₅₀	>40 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25871261]
SMMC-7721	IC₅₀	>40 μM Compound: 1	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25871261]
SW480	IC₅₀	>40 μM Compound: 1	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25871261]

In Vitro

Hyperforin has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca²⁺, K⁺, and Na⁺)^[2].
Hyperforin (0.1, 1, 10 μM; 2 h) reduces the expression and secretion of IL-17A in γδ T cell in vitro cultured murine splenic γδ T cells^[3].
Hyperforin (0.1, 1, 10 μM; 2 h) suppresses phosphorylation of MAPK and STAT3 pathways in TNF-α stimulated HaCaT cells^[3].
Hyperforin (IC₅₀=3.7 μmol/L) inhibits the microvascular tube formation and proliferation of HDMEC in a dose-dependent manner without toxic effects^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

HaCaT cells
Concentration:

0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α
Incubation Time:

2 hours
Result:

Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.

In Vivo

Hyperforin (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

IMQ-induced psoriasis-like mice model^[3]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection; once daily for 7 days
Result:

Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.
Suppressed infiltration of CD3+ T cells and downregulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.

Chemical Information

CAS No. 11079-53-1
Molecular Weight 536.78
Formula C₃₅H₅₂O₄
SMILES

CC(C)C([C@@]12[C@@](C)([C@H](C[C@](C/C=C(C)/C)(C(C(C/C=C(C)/C)=C2O)=O)C1=O)C/C=C(C)/C)CC/C=C(C)/C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All Bio/Physico-chemical AssayWB

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Mol Metab

TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis. [Abstract]

2026 Apr:106:102341. PMID: 41747880

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Primary brown adipocytes loaded with Fluo-4 AM. Baseline [Ca²⁺]_i was acquired. Primary brown adipocytes, incubated in Ca²⁺-containing or Ca²⁺-free bath solutions, were exposed to HPF (Hyperforin dicyclohexylammonium salt, 5 μM) at 150 s.

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Primary brown adipocytes were treated with vehicle (Ctrl) or HPF (Hyperforin dicyclohexylammonium salt, 5 μM) for 48 h. The protein levels of UCP1, PGC-1α, β-Actin, and p38 MAPK (n = 3).

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Trpc6^−/− adipocytes were treated with vehicle or HPF (Hyperforin dicyclohexylammonium salt, 5 μM) for 48 h.
Drug Discov Ther

TRPC6 expression is negatively correlated with breast cancer progression. [Abstract]

2025 Oct 16. PMID: 41093589
Transfus Med

Improvement of platelet preservation by inhibition of TRPC6. [Abstract]

2023 Jun;33(3):232-243. PMID: 36746770

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13. [Content Brief]

[2]. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456. [Content Brief]

[3]. Zhang S, et al. Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A-Producing γδ T Cells. Front Immunol. 2021 May 5;12:635076. [Content Brief]

[4]. Adam P, et al. Biosynthesis of hyperforin in Hypericum perforatum. J Med Chem. 2002 Oct 10;45(21):4786-93. [Content Brief]

[5]. Li XX, et al. Hyperforin: A natural lead compound with multiple pharmacological activities. Phytochemistry. 2023 Feb;206:113526. [Content Brief]

[6]. Suzhen Chen, et al. "The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity." Cell Metabolism 33.3 (2021): 565-580. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References

1/16
1/16

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Customer Validation
Primary brown adipocytes loaded with Fluo-4 AM. Baseline [Ca²⁺]_i was acquired. Primary brown adipocytes, incubated in Ca²⁺-containing or Ca²⁺-free bath solutions, were exposed to HPF (Hyperforin dicyclohexylammonium salt, 5 μM) at 150 s.
1/16

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Customer Validation
Primary brown adipocytes were treated with vehicle (Ctrl) or HPF (Hyperforin dicyclohexylammonium salt, 5 μM) for 48 h. The protein levels of UCP1, PGC-1α, β-Actin, and p38 MAPK (n = 3).
1/16

Hyperforin purchased from MedChemExpress. Usage Cited in: Mol Metab. 2026 Apr:106:102341. [Abstract]

Customer Validation
Trpc6^−/− adipocytes were treated with vehicle or HPF (Hyperforin dicyclohexylammonium salt, 5 μM) for 48 h.

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Hyperforin

Publications Citing Use of MedChemExpress (MCE) Hyperforin

All Calcium Channel Isoforms

All TRP Channel Isoforms