Brevetoxin B
Based on 1 Customer Validation
Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and calcium currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.0%
- No. CAS: 79580-28-2
- Fòrmula: C50H70O14
- Peso molecular:895.08
-
Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Calcium Channel
MoreVer todos los productos específicos de isoformas Caspase
More
Actividad biológica
|
Caspase 3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C6 | EC50 |
13 μM
Compound: BTXB
|
Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
|
[PMID: 22560474] |
Brevetoxin-B (0.011-1.11 μM; 10 min) concentration-dependently modulates multiple presynaptic ion currents at motor nerve terminals in mouse sternal deltoid muscle preparations: at a concentration of 0.11 μM, it enhances sodium and potassium currents while inhibiting calcium-activated potassium currents and slow calcium currents; at a concentration of 1.11 μM, it inhibits all detected ion currents[1].
Brevetoxin B (0-10 μg/mL; 0-48 h) affects the viability of Jurkat cells, causing a significant concentration- and time-dependent decrease in cellular metabolic activity[2].
Brevetoxin B (0-10 μg/mL; 3 h) significantly induces caspase-3-dependent apoptosis in Jurkat cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Jurkat
-
Concentration:0, 2, 4, 6, 8 and 10 μg/mL
-
Incubation Time:3, 24, 48 h
-
Result:Remained greater than 94% at all tested concentrations with no significant decrease compared to controls after 3 h.
Significantly decreased compared to controls at concentrations of 1.25 μg/mL or greater after 24 h.
Dropped to less than 30% at all tested concentrations after 48 h.
Chemical Information
-
No. CAS 79580-28-2
-
Appearance Solid
-
Peso molecular 895.08
-
Fòrmula C50H70O14
-
Color White to off-white
-
SMILES
C[C@@]1(O[C@](C)(CC[C@@](O[C@@](C[C@](C)(O[C@@](C(C)=CC2=O)([H])[C@](O2)([H])C3)[C@]3([H])O4)([H])[C@]4([H])C5)([H])[C@]([C@@H]5C)([H])O6)[C@]6([H])C7)[C@]7([H])O[C@]8(C)[C@@](O[C@](C[C@](O[C@@](C)([C@H]9O)[C@@](O[C@H](CC(C=O)=C)C9)([H])C%10)([H])[C@@]%10([H])O%11)([H])[C@@]%11([H])/C=C\C8)([H])C1
-
Synonyms
Brevetoxin-2; PbTx-2
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
-
Ficha de datos (272 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Tsai MC, et al. Effects of brevetoxin-B on motor nerve terminals of mouse skeletal muscle. Br J Pharmacol. 1991;103(1):1126-1128. [Content Brief]
[2]. Walsh CJ, et al. Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat). Mar Drugs. 2008;6(2):291-307. Published 2008 Jun 10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brevetoxin B Related Classifications
HY-12546 Related Classifications
Powered by Bioz