Asns - asparagine synthetase (glutamine-hydrolyzing) Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25612

Summary

Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to follicle-stimulating hormone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Apr 2022]

Asns Products (1)

mRNA Protein Name
NM_013079.2 NP_037211.2 asparagine synthetase [glutamine-hydrolyzing]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables asparagine synthase (glutamine-hydrolyzing) activity IDA
IDA: Inferred from direct assay
6132621 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
6132621 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in amino acid metabolic process IEP
IEP: Inferred from expression pattern
7818476 RGD
involved in asparagine biosynthetic process IDA
IDA: Inferred from direct assay
2887559 RGD
involved in cellular response to glucose starvation IEP
IEP: Inferred from expression pattern
10085239 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
1543496 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
237754 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
9176161 RGD
involved in response to follicle-stimulating hormone IEP
IEP: Inferred from expression pattern
7915898 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
16885923 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
16864689 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
6104809 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
6122150 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
18164361 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

asparagine synthetase [glutamine-hydrolyzing]

  • glutamine-dependent asparagine synthetase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-132254 Sacituzumab govitecan Inhibitor 99.13% Unkown
HY-132254A Sacituzumab govitecan (solution) Inhibitor 99.19% Unkown
HY-N0667 L-Asparagine 99.78% Unkown
HY-W017443 L-Asparagine monohydrate 99.77% Unkown
HY-14874 Topiroxostat Inhibitor 99.06% Unkown
HY-123319 Antofloxacin hydrochloride Inhibitor / Unkown
HY-123319A Antofloxacin Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-103018 Gusacitinib Inhibitor 99.63% Phase 2
HY-103018A Gusacitinib hydrochloride Inhibitor / Phase 2
HY-136579 ASN007 Inhibitor 99.48% Phase 1
HY-160196 HC-7366 Inhibitor 99.58% Phase 1
HY-136579A ASN007 benzenesulfonate Inhibitor 99.72% Phase 1

Pre-clinical Phase

Bioactive Molecules (127)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-128946 CL2A-SN-38 99.97% Unkown
HY-128923 SKF-34288 hydrochloride Inhibitor 98.61% Unkown
HY-136626 Z-Ala-Ala-Asn-AMC 99.28% Unkown
HY-W002327 Fmoc-Asn(Trt)-OH 99.96% Unkown
HY-108625 SHA 68 Antagonist 99.84% Unkown
HY-112205A RR-11a analog Inhibitor 99.12% Unkown
HY-164668 ADC Control Human IgG1-SN-38 97.53% Unkown
HY-N0667S2 L-Asparagine-15N2 monohydrate 99.95% Unkown
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.77% Unkown
HY-139147 iHCK-37 Inhibitor 99.52% Unkown
HY-175282 ASX-173 98.47% Unkown
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.55% Unkown
HY-W010378 D-Asparagine 98.0% Unkown
HY-156586 Egalognastat Inhibitor 99.03% Unkown
HY-N9446 H-Asn(glcnac-beta-D)-OH 98.65% Unkown
HY-P1341 OXA(17-33) 97.48% Unkown
HY-P1043A NGR peptide Trifluoroacetate 98.91% Unkown
HY-N0667S3 L-Asparagine-13C4 monohydrate 98.9% Unkown
HY-W009085 Fmoc-Asn-OH 99.19% Unkown
HY-111323 ASN06917370 99.23% Unkown
HY-W017443S L-Asparagine-13C4,15N2 monohydrate 98.0% Unkown
HY-128111 ASN02563583 Activator 99.21% Unkown
HY-B1803A Tracazolate hydrochloride Modulator 99.24% Unkown
HY-E70068 Endo-β-N-acetylglucosaminidase (Endo S) / Unkown
HY-N0667S5 L-Asparagine-d3 hydrate 99.64% Unkown
HY-148393 G0 N-glycan-Asn 99.95% Unkown
HY-113667 ASN04885796 Activator 99.61% Unkown
HY-P11200 γ-Glu-Asn 98.12% Unkown
HY-W013330 3′-Deoxyguanosine 97.0% Unkown
HY-P4279 Ovalbumin (154-159) Inhibitor 99.18% Unkown
HY-125028 Hck-IN-1 Inhibitor 98.10% Unkown
HY-150242A Cbz-Ala-Ala-Asn TFA 99.54% Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% Unkown
HY-162238 OSM-S-106 Inhibitor 99.34% Unkown
HY-150787 BMS-986339 99.74% Unkown
HY-128128 ASN04421891 Modulator 99.00% Unkown
HY-131092A H-Asn-Arg-OH diTFA 99.83% Unkown
HY-141464 Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH 95.03% Unkown
HY-175282A (2S,3R,4S)-ASX-173 Control 99.29% Unkown
HY-P10485 Glp-Asn-Pro-AMC 99.26% Unkown
HY-P1809A Velmupressin acetate Agonist 99.47% Unkown
HY-P1962 β-Secretase inhibitor Inhibitor 98.06% Unkown
HY-W010378R D-Asparagine (Standard) 99.90% Unkown
HY-129360A Ala-Ala-Asn-PAB TFA / Unkown
HY-156314 ASN 07115873 Inhibitor 98.76% Unkown
HY-172473 DSPE-PEG2000-NGR 95.0% Unkown
HY-176977 Exatecan-mpGly-Asn-Asn-(βAla) 96.25% Unkown
HY-180467 Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me / Unkown
HY-180467A Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium / Unkown
HY-78162 cis-3-Hydroxyproline Substrate 95.0% Unkown
HY-N0667S L-Asparagine-13C4,15N2,d8 99% Unkown
HY-N0667S1 L-Asparagine-15N2,d8 / Unkown
HY-P3882 Fmoc-Ala-Glu-Gln-Lys-NH2 99.26% Unkown
HY-W008233 Z-Asn-OH 98.76% Unkown
HY-W017443S1 L-Asparagine-amide-15N monohydrate 99.80% Unkown
HY-148389 Disialo-Asn 98.04% Unkown
HY-W017443S2 L-Asparagine-13C4,15N2,d3 monohydrate 99.90% Unkown
HY-W142294 Ac-D-Asn-OH / Unkown
HY-P1809 Velmupressin Agonist / Unkown
HY-P1810 c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm Agonist / Unkown
HY-P1043 NGR peptide 99.73% Unkown
HY-103018S Gusacitinib-d4 / Unkown
HY-113761 ASN03576800 Inhibitor 99.61% Unkown
HY-122179 NUCC-555 Antagonist / Unkown
HY-128947 CL2 Linker / Unkown
HY-129360 Ala-Ala-Asn-PAB / Unkown
HY-129361 Fmoc-Ala-Ala-Asn-PABC-PNP / Unkown
HY-130933 Fmoc-Ala-Ala-Asn(Trt)-OH 99.80% Unkown
HY-131463 ASN-1377642 Antagonist / Unkown
HY-136733 Ac-DNLD-CHO Inhibitor / Unkown
HY-139245 MC-Ala-Ala-Asn-PAB / Unkown
HY-141149 Fmoc-PEG4-Ala-Ala-Asn-PAB / Unkown
HY-141150 Azido-PEG5-Ala-Ala-Asn-PAB / Unkown
HY-141151 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB / Unkown
HY-144628 Fmoc-Asn-Pro-Val-PABC-PNP 99.34% Unkown
HY-144629 Asn-Pro-Val-PABC-MMAE TFA / Unkown
HY-144630 diSPhMC-Asn-Pro-Val-PABC-MMAE / Unkown
HY-148031 MC-Ala-Ala-Asn-PAB-PNP / Unkown
HY-148392 Neu5Gcα(2-6) N-Glycan-Asn / Unkown
HY-149360 P-gb-IN-1 Inhibitor / Unkown
HY-149825 MTHFD2-IN-1 Inhibitor / Unkown
HY-149826 MTHFD2-IN-2 Inhibitor / Unkown
HY-149827 MTHFD2-IN-3 Inhibitor / Unkown
HY-149828 MTHFD2-IN-4 Inhibitor / Unkown
HY-149828A MTHFD2-IN-4 sodium Inhibitor / Unkown
HY-151146 (1R,3S)-THCCA-Asn Inhibitor / Unkown
HY-164457 ASN-001 Inhibitor / Unkown
HY-172472 DSPE-PEG1000-NGR / Unkown
HY-172473A DSPE-PEG3400-NGR / Unkown
HY-172474 DSPE-PEG5000-NGR / Unkown
HY-174223 α-Glucosidase-IN-90 Inhibitor / Unkown
HY-183362 Antileishmanial agent-42 Inhibitor / Unkown
HY-185461 Mc-Asn-Asn-E104 Agonist / Unkown
HY-185462 Mc-Asn-Asn / Unkown
HY-E71264 β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron / Unkown
HY-N0667S4 L-Asparagine-4-13C monohydrate / Unkown
HY-N0667S7 L-Asparagine-13C4,15N2 / Unkown
HY-N15365 Antcin B Inhibitor / Unkown
HY-P11408 [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) Agonist / Unkown
HY-P11620 H-Asn-Pro-Glu-Tyr(PO3H2)-OH / Unkown
HY-P1610 Asudemotide Inducer / Unkown
HY-P2212 (Asn1,Val5)-Angiotensin II / Unkown
HY-P2397 Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OH / Unkown
HY-P2401 Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH / Unkown
HY-P3220 [D-Asn5]-Oxytocin Activator / Unkown
HY-P3615 [Asn18] Endothelin-1 (swine, human) Agonist / Unkown
HY-P3716 H(-Asn-Pro-Asn-Ala)2-OH / Unkown
HY-P4019 Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 / Unkown
HY-P4407 (D-Asn28)-Exenatide Control / Unkown
HY-P4919 Mca-SEVNLDAEFK(Dnp) / Unkown
HY-P5415 DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS / Unkown
HY-RS01098 ASNS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W017443S3 L-Asparagine-15N2,d3 monohydrate / Unkown
HY-W017443S4 L-Asparagine-1,2,3,4-13C4 monohydrate / Unkown
HY-W091365 Boc-Asn(Xan)-OH / Unkown
HY-W845197 L-Asparagine-15N2 / Unkown
HY-118731 TNK-6123 Activator / Unkown
HY-129286 ASN 05397535 / Unkown
HY-131092 H-Asn-Arg-OH / Unkown
HY-141152 Azido-PEG4-Ala-Ala-Asn(Trt)-PAB / Unkown
HY-141153 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP / Unkown
HY-151829 Fmoc-L-Asn(EDA-N3)-OH / Unkown
HY-157338 NHS-Ala-Ala-Asn-active metabolite Inhibitor / Unkown
HY-RS19117 Asns Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25607 Asns Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W002327S Fmoc-Asn(Trt)-OH-13C4,15N2 96.9% Unkown
HY-W173361 CBP/p300-IN-24 Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P992184 Anti-5T4 scFv-Fc Antibody / Unkown
HY-P991497 ASN-500 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asns NCBI NCBI:440