Methdilazine
Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.
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- No. CAS: 1982-37-2
- Fòrmula: C18H20N2S
- Peso molecular:296.43
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Actividad biológica
MIC: 5-15 μg/mL (mycobacterium)
Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mycobacterium: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus.
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Concentration:0-20 μg/mL approximately
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Incubation Time:18 h
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Result:Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:H37Rv infected mice[1]
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Dosage:10 μg/gm body wt/day, 6 weeks
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Administration:Intraperitoneal injection
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Result:Displayed an anti-mycobacterial activity to mycobacteria.
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Animal Model:Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2]
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Dosage:10 mg/kg per day for 28 days
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Administration:Oral administration
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Result:Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
Chemical Information
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No. CAS 1982-37-2
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Appearance Solid
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Peso molecular 296.43
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Fòrmula C18H20N2S
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SMILES
CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Referencias
[1]. A N Chakrabarty, et al. Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine. APMIS. 1993 Jun;101(6):449-54. [Content Brief]
[2]. Noton K Dutta, et al. Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice. J Med Microbiol. 2009 Dec;58(Pt 12):1667-1668. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methdilazine Related Classifications
HY-B1690 Related Classifications
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