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Cat. No.: HY-169076

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FLT3/HDAC-IN-1

FLT3/HDAC-IN-1 is a dual inhibitor of FLT3/HDAC, with IC₅₀ values of 30.4, 52.4, and 14.7 nM for FLT3, HDAC1, and HDAC3, respectively. FLT3/HDAC-IN-1 can induce apoptosis in MV-4-11 cells and has anti-proliferative effects on FLT3 mutant-transformed BaF3 cells. FLT3/HDAC-IN-1 is being researched for its potential in treating hard-to-treat solid tumors and hematological malignancies.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₄ClN₉O
Molecular Weight:501.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

FLT3/HDAC-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 9e	Antiproliferative activity against human A549 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human A549 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
BaF3	IC₅₀	130.87 nM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring FLT3 D835V mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against mouse BaF3 cells harboring FLT3 D835V mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
BaF3	IC₅₀	139.03 nM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD/D835Y double mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD/D835Y double mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
BaF3	IC₅₀	286.23 nM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring FLT3 F691L mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against mouse BaF3 cells harboring FLT3 F691L mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
BaF3	IC₅₀	326.25 nM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD mutant assessed as cell viability incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
CESS	IC₅₀	0.6 μM Compound: 9e	Antiproliferative activity against human CESS cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human CESS cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
HT-29	IC₅₀	1.14 μM Compound: 9e	Antiproliferative activity against human HT-29 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human HT-29 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
KG-1	IC₅₀	0.47 μM Compound: 9e	Antiproliferative activity against human KG-1 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human KG-1 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
MV4-11	IC₅₀	0.03 μM Compound: 9e	Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
PBMC	IC₅₀	384.27 nM Compound: 9e	Cytotoxicity against human PBMC cells incubated for 3 days by celltiter-glo luminescent assay Cytotoxicity against human PBMC cells incubated for 3 days by celltiter-glo luminescent assay	[PMID: 39178382]
PC-9	IC₅₀	0.19 μM Compound: 9e	Antiproliferative activity against human PC-9 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human PC-9 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
Rec1	IC₅₀	0.27 μM Compound: 9e	Antiproliferative activity against human REC1 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human REC1 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]
ZR-75-1	IC₅₀	>20 μM Compound: 9e	Antiproliferative activity against human ZR-75-1 cells incubated for 72 hrs by celltiter-glo luminescent assay Antiproliferative activity against human ZR-75-1 cells incubated for 72 hrs by celltiter-glo luminescent assay	[PMID: 39178382]

Chemical Information

Molecular Weight 501.97
Formula C₂₅H₂₄ClN₉O
SMILES

ClC1=CN=C(N=C1C2=CN=C3N2C=CC=C3)NC4=CN(N=C4)CC5=CC=C(C=C5)C(NNCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saidahmatov A, et al. Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies. J Med Chem. 2024 Sep 12;67(17):15220-15245. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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FLT3/HDAC-IN-1

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

FLT3/HDAC-IN-1 Related Classifications

HY-169076 Related Classifications