FT895
Based on 2 publication(s) in Google Scholar
FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.84%
- No. CAS: 2225728-57-2
- Fòrmula: C16H15F3N4O2
- Peso molecular:352.31
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) FT895
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In Vivo Efficacy Study
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IHC
Actividad biológica
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HDAC11 3 nM (IC50) |
FT895 is a highly selective HDAC11 inhibitor showing greater than 1000-fold selectivity against the other 10 members of the HDAC family[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2225728-57-2
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Appearance Solid
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Peso molecular 352.31
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Fòrmula C16H15F3N4O2
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Color White to light yellow
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SMILES
O=C(NO)C1=C(CN(C2=CN=C(C(F)(F)F)C=N2)C3(C)C)C3=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Redox Biol
HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3. [Abstract]2022 Oct:56:102461. PMID: 36087429
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
iNOS proteins. WT BMDM cells were unstimulated or stimulated with 100 μg/mL zymosan for 24 h in the presence of FT895 or STAT3-IN-1 alone, or FT895 and STAT3-IN-1 in combination. Cell lysates were performed for immunoblotting with iNOS antibody.
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
NO production. WT BMDM cells were unstimulated or stimulated with 100 μg/mL zymosan in the presence of FT895 or STAT3-IN-1 alone, or FT895 and STAT3-IN-1 in combination for 48 h. NO levels in culture supernatants were measured by nitrite assay.
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
WT C57BL/6 mice were intravenously injected with 2 × 105 CFU of C. albicans per mouse, then randomly divided into three groups (n = 10 mice for each group) and 24 h later intraperitoneally administered with HDAC11 inhibitors FT895 (50 mg/kg body weight) or SIS17 (100 mg/kg body weight) or equal volume of DMSO as control per day for 4 consecutive days. Assess mouse survival rate.
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
Kidney fungal burden. WT mice were infected intravenously with 2 × 105 CFU of C. albicans per mouse, and 24 h later treated with DMSO, FT895, or SIS17 (n = 3 mice for each group). After an additional 48 h, the kidneys were isolated and the fungal burden was determined by YPD plate assay.
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
Kidney sections from DMSO or HDAC11 inhibitor FT895 treated mice infected C.albicans were stained with H&E and PAS. Insets show regions of inflammation and fungal growth, respectively. Representative images of at least three replicates are shown. Scale bar, 500 μm.
FT895 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct:56:102461. [Abstract]
NOS2 mRNA triggered in human cells. Human monocyte cell line THP-1 (left panel) and primary peripheral blood mononuclear cells (hPBMC, right panel) were stimulated with 10 MOI of HKCA for the indicated times in the presence of FT895 (10 μM) or DMSO as control. Total RNA was extracted and NOS2 mRNA levels were measured by qPCR. β-actin house keep gene was used as reference.
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Solvente y solubilidad
DMSO : 125 mg/mL (354.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
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- Deutsch - DE (251 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8384 mL | 14.1920 mL | 28.3841 mL | 70.9602 mL |
| 5 mM | 0.5677 mL | 2.8384 mL | 5.6768 mL | 14.1920 mL | |
| 10 mM | 0.2838 mL | 1.4192 mL | 2.8384 mL | 7.0960 mL | |
| 15 mM | 0.1892 mL | 0.9461 mL | 1.8923 mL | 4.7307 mL | |
| 20 mM | 0.1419 mL | 0.7096 mL | 1.4192 mL | 3.5480 mL | |
| 25 mM | 0.1135 mL | 0.5677 mL | 1.1354 mL | 2.8384 mL | |
| 30 mM | 0.0946 mL | 0.4731 mL | 0.9461 mL | 2.3653 mL | |
| 40 mM | 0.0710 mL | 0.3548 mL | 0.7096 mL | 1.7740 mL | |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5677 mL | 1.4192 mL | |
| 60 mM | 0.0473 mL | 0.2365 mL | 0.4731 mL | 1.1827 mL | |
| 80 mM | 0.0355 mL | 0.1774 mL | 0.3548 mL | 0.8870 mL | |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7096 mL |
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