Referencia número: HY-100384

NKL 22

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

NKL 22 is a potent and selective inhibitor of histone deacetylases (HDAC), with IC₅₀ values of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 can reverse abnormal expression of HD‑related genes and restore the levels of key genes including Ppp1r1b in Huntington's disease transgenic mice. NKL 22 can be used for the researches of Huntington's disease and cancer.

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Pureza: 97.26%
No. CAS: 537034-15-4
Fòrmula: C₁₉H₂₃N₃O₂
Peso molecular:325.40

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

NKL 22 Chemical Structure

No. CAS: 537034-15-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[2]

HDAC3

0.069 μM (IC₅₀)

HDAC1

0.199 μM (IC₅₀)

HDAC2

1.59 μM (IC₅₀)

HDAC8

5 μM (IC₅₀)

Ver todos los productos específicos de isoformas HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	78 μM Compound: 4b	Inhibition of HDAC in human HeLa cell extract by fluorescence plate reader assay Inhibition of HDAC in human HeLa cell extract by fluorescence plate reader assay	[PMID: 16921367]

In Vitro

NKL 22 (Compound 4b) shows IC₅₀ values of 199 and 69 nM for HDAC1 and HDAC3, respectively, and shows IC₅₀ values of 1.59 and 5 μM for HDAC4/8 >180 μM for HDAC4/5/7^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NKL 22 (Compound 4b) (150 mg/kg, s.c., once daily for 3 consecutive days) reverses abnormal expression of HD‑related genes and restores the levels of key genes including Ppp1r1b in Huntington’s disease transgenic mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

R6/2/N171-82Q Huntington’s disease transgenic mice^[2]
Dosage:

150 mg/kg
Administration:

s.c., once daily for 3 consecutive days
Result:

Reversed abnormal expression of HD‑related genes and restored the levels of key genes including Ppp1r1b.
Ameliorated motor and behavioral phenotypes.
Did not alter the total expression of HDAC1/3 but promotes their nuclear accumulation in N171-82Q Huntington’s disease transgenic mice.

Chemical Information

No. CAS 537034-15-4
Appearance Solid
Peso molecular 325.40
Fòrmula C₁₉H₂₃N₃O₂
Color White to off-white
SMILES

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

J Mol Med (Berl)

Combination of PARP inhibitor and temozolomide to suppress chordoma progression. [Abstract]

2019 Aug;97(8):1183-1193. PMID: 31201471

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (307.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0731 mL

15.3657 mL

30.7314 mL

5 mM

0.6146 mL

3.0731 mL

6.1463 mL

10 mM

0.3073 mL

1.5366 mL

3.0731 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. He S, et al. Histone Deacetylase Inhibitor Entinostat Exerts Anti-NSCLC Effects Through the EGFR Signaling Pathway and MDM2-p53 Axis. Curr Pharm Biotechnol. Published online January 5, 2026. [Content Brief]

[2]. Jia H, et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012;46(2):351-361. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0731 mL	15.3657 mL	30.7314 mL	76.8285 mL
	5 mM	0.6146 mL	3.0731 mL	6.1463 mL	15.3657 mL
	10 mM	0.3073 mL	1.5366 mL	3.0731 mL	7.6829 mL
	15 mM	0.2049 mL	1.0244 mL	2.0488 mL	5.1219 mL
	20 mM	0.1537 mL	0.7683 mL	1.5366 mL	3.8414 mL
	25 mM	0.1229 mL	0.6146 mL	1.2293 mL	3.0731 mL
	30 mM	0.1024 mL	0.5122 mL	1.0244 mL	2.5610 mL
	40 mM	0.0768 mL	0.3841 mL	0.7683 mL	1.9207 mL
	50 mM	0.0615 mL	0.3073 mL	0.6146 mL	1.5366 mL
	60 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2805 mL
	80 mM	0.0384 mL	0.1921 mL	0.3841 mL	0.9604 mL
	100 mM	0.0307 mL	0.1537 mL	0.3073 mL	0.7683 mL

Keywords

NKL 22

1 Cited Publications

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NKL 22

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) NKL 22

Ver todos los productos específicos de isoformas HDAC

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

NKL 22

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) NKL 22

Ver todos los productos específicos de isoformas HDAC

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

NKL 22 Related Classifications

HY-100384 Related Classifications