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Referencia número: HY-187195

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Abd141

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia.
(Pink: ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₄₃H₄₄N₈O₇S
Peso molecular:816.92

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Abd141 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia^[1]. (Pink: ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

IC₅₀ & Target

^[1]

Aurora A

6.7 nM (DC₅₀)

ATR

97.7 nM (DC₅₀)

Cereblon

97 nM (Kd)

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas ATM/ATR :

Ver todos los productos específicos de isoformas Aurora Kinase :

In Vitro

OthersAnti-cancerApoptosis

Others

Abd141 binds to CRBNmidi, with a measured K_d value of 97 nM determined by MST at 25 °C^[1].

Anti-cancer

Abd141 (10 nM-5 μM; 24 h) potently degrades ATR (DC₅₀ = 97.7 nM) and Aurora A (DC₅₀ = 6.7 nM) after 24-hour incubation in MOLT-4 acute lymphoblastic leukemia cells, and does not affect the level of WEE1 at a concentration of 500 nM^[1].
Abd141 (0.5 μM; 24-120 h) inhibits the proliferation of MOLT-4 acute lymphoblastic leukemia cells in a CRBN-dependent manner^[1].

Anti-cancer

Apoptosis

Abd141 (0.5 μM; 24 h) enhances Cytarabine (HY-13605)-induced apoptosis of MOLT-4 acute lymphoblastic leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MOLT-4 wild-type and MOLT-4ΔCRBN cells
Concentration:

0.5 μM
Incubation Time:

24 h, 96 h, 120 h
Result:

Stalled MOLT-4 wild-type cell growth, with significantly lower cell numbers at 96 h and 120 h compared to untreated controls.
Showed no growth suppression in MOLT-4ΔCRBN cells.

Apoptosis Analysis^[1]

Cell Line:

MOLT-4 cells
Concentration:

0.5 μM Abd141; 0.5 μM Cytarabine
Incubation Time:

24 h
Result:

Did not induce significant apoptosis when used alone.
Augmented Cytarabine-induced apoptosis from 34% to 62%.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

Peso molecular 816.92
Fòrmula C₄₃H₄₄N₈O₇S
SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCC3CCN(C(CCCC#CC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC3)=O)C=C2)=CN=C1N)NC7=CC=CC=C7
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Alfayomy AM, et al. Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells. European journal of medicinal chemistry. 2026 Jul 10;318:119125. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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Abd141

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas ATM/ATR

Ver todos los productos específicos de isoformas Aurora Kinase