Cefoperazone
Based on 7 publication(s) in Google Scholar
Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.72%
- No. CAS: 62893-19-0
- Fòrmula: C25H27N9O8S2
- Peso molecular:645.67
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
FDA-Approved Drug Library
HY-L022
-
Drug Repurposing Compound Library
HY-L035
-
Antibacterial Compound Library
HY-L049
-
Anti-COVID-19 Compound Library
HY-L052
-
NMPA-Approved Drug Library
HY-L053
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Antibiotics Library
HY-L067
-
Rare Diseases Drug Library
HY-L102
-
Human Metabolite Library
HY-L123
-
Off-patent Drug Library
HY-L141
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
FDA-Approved Drug Library Plus
HY-L022P
-
FDA-Approved Drug Library Mini
HY-L022M
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Classic FDA-Approved Drug Library
HY-L261
Publications Citing Use of MedChemExpress (MCE) Cefoperazone
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Carbohydr Polym. 2024 Jan 1:323:121379. [Abstract]
- Mol Med. 2024 Nov 6;30(1):203. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Ther Adv Med Oncol. 2026 Jan 2:18:17588359251409010. [Abstract]
- Toxicol Appl Pharmacol. 2023 Apr 1:464:116447. [Abstract]
- J Antibiot (Tokyo). 2023 Apr;76(4):225-235. [Abstract]
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
|
β-lactam |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 4a
|
Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human A549 cells after 72 hrs by Alamar Blue assay
|
[PMID: 18752870] |
| MCF7 | IC50 |
>100 μM
Compound: 4a
|
Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay
|
[PMID: 18752870] |
| Oocyte | IC50 |
298 μM
Compound: Cefoperazone
|
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
|
[PMID: 15618660] |
Cefoperazone (Aerosol treatment, 60 μg/mL final concentration in lung homogenate) protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 62893-19-0
-
Appearance Solid
-
Peso molecular 645.67
-
Fòrmula C25H27N9O8S2
-
Color White to off-white
-
SMILES
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](NC(N4C(C(N(CC)CC4)=O)=O)=O)C5=CC=C(O)C=C5)=O)C1=O)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Carbohydr Polym
Preparation of bacterial cellulose-based antibacterial membranes with prolonged release of drugs: Emphasis on the chemical structure of drugs. [Abstract]2024 Jan 1:323:121379. PMID: 37940275 -
Mol Med
Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation. [Abstract]2024 Nov 6;30(1):203. PMID: 39508252 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Ther Adv Med Oncol
Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer. [Abstract]2026 Jan 2:18:17588359251409010. PMID: 41487693 -
Toxicol Appl Pharmacol
2023 Apr 1:464:116447. PMID: 36889513 -
J Antibiot (Tokyo)
Impact of short chain fatty acids (SCFAs) on antimicrobial activity of new β-lactam/β-lactamase inhibitor combinations and on virulence of Escherichia coli isolates. [Abstract]2023 Apr;76(4):225-235. PMID: 36726014
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (154.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.87 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.87 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
-
Ficha de datos (275 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5488 mL | 7.7439 mL | 15.4878 mL | 38.7195 mL |
| 5 mM | 0.3098 mL | 1.5488 mL | 3.0976 mL | 7.7439 mL | |
| 10 mM | 0.1549 mL | 0.7744 mL | 1.5488 mL | 3.8719 mL | |
| 15 mM | 0.1033 mL | 0.5163 mL | 1.0325 mL | 2.5813 mL | |
| 20 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9360 mL | |
| 25 mM | 0.0620 mL | 0.3098 mL | 0.6195 mL | 1.5488 mL | |
| 30 mM | 0.0516 mL | 0.2581 mL | 0.5163 mL | 1.2906 mL | |
| 40 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9680 mL | |
| 50 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
| 60 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6453 mL | |
| 80 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL | |
| 100 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL |
Cefoperazone Related Classifications
HY-B0210 Related Classifications
Powered by Bioz