Etoperidone
Based on 1 Customer Validation
Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively.
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- No. CAS: 52942-31-1
- Fòrmula: C19H28ClN5O
- Peso molecular:377.91
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Ver todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
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5-HT1A Receptor |
5-HT1A Receptor 85 nM (Kd) |
5-HT2A Receptor 36 nM (Kd) |
α1-adrenergic receptor 38 nM (Kd) |
α2-adrenergic receptor 570 nM (Kd) |
Chemical Information
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No. CAS 52942-31-1
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Appearance Oil
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Peso molecular 377.91
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Fòrmula C19H28ClN5O
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SMILES
O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
DMSO : 100 mg/mL (264.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [Content Brief]
[2]. G W Caldwell, et al. Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man. Xenobiotica. 2001 Nov;31(11):823-39. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6461 mL | 13.2307 mL | 26.4613 mL | 66.1533 mL |
| 5 mM | 0.5292 mL | 2.6461 mL | 5.2923 mL | 13.2307 mL | |
| 10 mM | 0.2646 mL | 1.3231 mL | 2.6461 mL | 6.6153 mL | |
| 15 mM | 0.1764 mL | 0.8820 mL | 1.7641 mL | 4.4102 mL | |
| 20 mM | 0.1323 mL | 0.6615 mL | 1.3231 mL | 3.3077 mL | |
| 25 mM | 0.1058 mL | 0.5292 mL | 1.0585 mL | 2.6461 mL | |
| 30 mM | 0.0882 mL | 0.4410 mL | 0.8820 mL | 2.2051 mL | |
| 40 mM | 0.0662 mL | 0.3308 mL | 0.6615 mL | 1.6538 mL | |
| 50 mM | 0.0529 mL | 0.2646 mL | 0.5292 mL | 1.3231 mL | |
| 60 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL | 1.1026 mL | |
| 80 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8269 mL | |
| 100 mM | 0.0265 mL | 0.1323 mL | 0.2646 mL | 0.6615 mL |
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