Gamendazole
Based on 1 Customer Validation
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research.
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- Pureza: 99.44%
- No. CAS: 877773-32-5
- Fòrmula: C18H11Cl2F3N2O2
- Peso molecular:415.19
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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HSP90AB1 |
EEF1A1 |
Akt1 |
ErbB2 |
Chemical Information
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No. CAS 877773-32-5
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Appearance Solid
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Peso molecular 415.19
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Fòrmula C18H11Cl2F3N2O2
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Color White to off-white
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SMILES
O=C(/C=C/C1=NN(C2=C1C=CC(C(F)(F)F)=C2)CC3=CC=C(C=C3Cl)Cl)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (120.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4085 mL | 12.0427 mL | 24.0854 mL | 60.2134 mL |
| 5 mM | 0.4817 mL | 2.4085 mL | 4.8171 mL | 12.0427 mL | |
| 10 mM | 0.2409 mL | 1.2043 mL | 2.4085 mL | 6.0213 mL | |
| 15 mM | 0.1606 mL | 0.8028 mL | 1.6057 mL | 4.0142 mL | |
| 20 mM | 0.1204 mL | 0.6021 mL | 1.2043 mL | 3.0107 mL | |
| 25 mM | 0.0963 mL | 0.4817 mL | 0.9634 mL | 2.4085 mL | |
| 30 mM | 0.0803 mL | 0.4014 mL | 0.8028 mL | 2.0071 mL | |
| 40 mM | 0.0602 mL | 0.3011 mL | 0.6021 mL | 1.5053 mL | |
| 50 mM | 0.0482 mL | 0.2409 mL | 0.4817 mL | 1.2043 mL | |
| 60 mM | 0.0401 mL | 0.2007 mL | 0.4014 mL | 1.0036 mL | |
| 80 mM | 0.0301 mL | 0.1505 mL | 0.3011 mL | 0.7527 mL | |
| 100 mM | 0.0241 mL | 0.1204 mL | 0.2409 mL | 0.6021 mL |
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