KH-259
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3023019-93-1
- Fòrmula: C20H25N3O2
- Peso molecular:339.43
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
|
HDAC6 0.26 ± 0.2 μM (IC50) |
HDAC1 6.7 ± 0.14 μM (IC50) |
HDAC4 12.3 ± 0.4 μM (IC50) |
In Vitro
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 3023019-93-1
-
Peso molecular 339.43
-
Fòrmula C20H25N3O2
-
SMILES
CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KH-259 Related Classifications
HY-150503 Related Classifications
Powered by Bioz