Multiflorin A
Multiflorin A is an orally active active ingredient of traditional herbal laxative, Pruni semen. Multiflorin A inhibits aromatase enzyme activity with an IC50 of 15.5 μM. Multiflorin A also inhibits quinone reductase 2 (QR2) and COX-2 enzyme. Multiflorin A has purgative activity and reduces postprandial blood glucose in mice. Multiflorin A modulates intestinal glucose transporters, tight junction proteins, and aquaporins, reshapes gut microbiota, and alters faecal metabolites. Multiflorin A can be used for the research of constipation and diabetes.
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- No. CAS: 1350028-90-8
- Fòrmula: C29H32O16
- Peso molecular:636.55
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Aromatase 15.5 μM (IC50) |
COX-2 |
In Vitro
Multiflorin A potently inhibits aromatase enzyme activity with an IC50 of 15.5 μM[2].
Multiflorin A (11.5 μg/mL) inhibits QR2 enzyme activity by 39%[2].
Multiflorin A (10 μg/mL) stimulates COX-1 enzyme activity by 29% and inhibits COX-2 enzyme activity by 16%[2].
Multiflorin A (20 μg/mL; 6 h) does not inhibit TNF-α-induced NF-κB activity in human embryonic kidney 293 cells at a concentration of 20 μg/mL[2].
Multiflorin A (20 μg/mL) exhibits no significant cytotoxicity toward Hepa1c1c7 or MCF-7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Multiflorin A (10-20 mg/kg; i.g.; single dose) effectively reverses Loperamide hydrochloride (HY-B0418A)-induced constipation in male ICR mice, significantly reducing first stool time and increasing faecal water content[1].
Multiflorin A (10 mg/kg; i.g.; single dose) inhibits postprandial blood glucose elevation in male ICR mice, with effects persisting for at least 6 h after administration[1].
Multiflorin A (10-20 mg/kg; i.g.; daily; 3 days) modulates intestinal glucose transporters, tight junction proteins, and aquaporins, reshapes gut microbiota, and alters faecal metabolites in male ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR (male, 24-26 g)[1]
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Dosage:20 mg/kg; 40 mg/kg
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Administration:p.o.; single dose
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Result:Induced watery diarrhoea in 62% of mice, significantly decreased the time to first red stool, and significantly increased faecal water content compared to controls at 20 mg/kg.
Induced watery diarrhoea in 100% of mice, significantly decreased the time to first red stool, and significantly increased faecal water content compared to controls at 40 mg/kg.
Caused noticeable watery diarrhoea and intestinal distension in fed mice, while fasted mice showed no watery diarrhoea.
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Animal Model:ICR (male, 24-26 g, loperamide-induced constipation)[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:p.o.; single dose
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Result:Significantly decreased the time to first red stool and significantly increased faecal water content compared to the loperamide-induced constipation model group at 10 mg/kg.
Significantly decreased the time to first red stool and significantly increased faecal water content compared to the loperamide-induced constipation model group at 20 mg/kg.
Chemical Information
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No. CAS 1350028-90-8
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Appearance Solid
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Peso molecular 636.55
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Fòrmula C29H32O16
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Color Off-white to yellow
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SMILES
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(C=C3)O)=C1O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)COC(C)=O)O)O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (298 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multiflorin A Related Classifications
HY-N12326 Related Classifications
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