NHNB
NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection.
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- No. CAS: 106359-61-9
- Fòrmula: C17H13NO2
- Peso molecular:263.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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hHDAC8 66 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RBL-1 | IC50 |
0.18 μM
Compound: 16
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In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
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[PMID: 2308149] |
| RBL-1 | IC50 |
0.18 μM
Compound: 49
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In vitro inhibitory activity against RBL-1 5-LO
In vitro inhibitory activity against RBL-1 5-LO
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[PMID: 3820229] |
NHNB (Compound 4) inhibits recombinant human HDAC8 with an IC50 of 66.0 μM[1].
NHNB (0-5000 μM; 5 min) acts as a competitive inhibitor of purified B. cereus BC1974 peptidoglycan deacetylase with an IC50 of 43.3 μM and a Ki of 8.7 μM[2].
NHNB (0-5000 μM; 10 min) acts as a competitive inhibitor of purified B. cereus BC1960 peptidoglycan deacetylase with an IC50 of 132 μM and a Ki of 66.0 μM[2].
NHNB (4 μg/mL; 16 h) induces onger chains of daughter cell production in B. cereus and B. anthracis[2].
NHNB shows MICs of 5.26-7.89 μg/mL and MBcs of 8.23 μg/mL for B. cereus ATCC
14,579 and B. anthracis 7702[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 106359-61-9
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Peso molecular 263.29
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Fòrmula C17H13NO2
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SMILES
O=C(C1=CC=C(C2=CC=CC3=C2C=CC=C3)C=C1)NO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007;17(10):2874-2878. [Content Brief]
[2]. Balomenou S, et al. Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus. Bioorg Med Chem. 2018;26(13):3845-3851. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NHNB Related Classifications
HY-115442 Related Classifications
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