Revaprazan
Based on 2 publication(s) in Google Scholar
Revaprazan (SB 641257) is reversible proton pump inhibitor. Revaprazan can inhibit gastric acid secretion and protect gastric mucosa. Revaprazan can inhibit IkappaB-alpha degradation as well as Akt inactivation, resulting in attenuation of H. pylori-induced COX-2 expression. Revaprazan can be used for the researches of infection and inflammmation, such as H. pylori-infected gastric inflammation and gastric ulcer.
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- No. CAS: 199463-33-7
- Fòrmula: C22H23FN4
- Peso molecular:362.44
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Almacenamiento:
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Publications Citing Use of MedChemExpress (MCE) Revaprazan
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Actividad biológica
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COX-2 |
Revaprazan (5-20 μM, 24 h) reduces H. pylori-stimulated COX-2 expression and activity in AGS cells[1].
Revaprazan (5-20 μM, 24 h) inhibits transcription activity of NF-κB in H. pylori-stimulated AGS cells[1].
Revaprazan (5-20 μM, 24 h) improves the retarded cell growth in H. pylori-stimulated AGS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H. pylori-stimulated AGS cells
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Concentration:5 and 20 μM
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Incubation Time:24 h
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Result:Reduced COX-2 expression.
Inhibited transcription activity of NF-κB.
Inactivated ERK and Akt phosphorylation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 199463-33-7
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Peso molecular 362.44
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Fòrmula C22H23FN4
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SMILES
CC1=C(C)C(N2C(C)C3=C(C=CC=C3)CC2)=NC(NC4=CC=C(F)C=C4)=N1
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Synonyms
SB 641257
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells. [Abstract]2022 Sep 25;15(10):1186. PMID: 36297298 -
BMC Microbiol
In vitro combination effects and mechanisms of Revaprazan with Triazole antifungal drugs on Aspergillus. [Abstract]2025 Nov 5;25(1):715. PMID: 41194018
Pureza y Documentación
Referencias
[1]. Lee JS, et al. Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012 Sep;51(2):77-83. [Content Brief]
[2]. Kim HK, et al. Clinical trial: inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects. J Gastroenterol Hepatol. 2010 Oct;25(10):1618-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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