RXP470.1
Based on 1 Customer Validation
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.60%
- No. CAS: 891198-31-5
- Fòrmula: C35H35BrClN4O10P
- Peso molecular:818.00
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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human MMP-12 0.2 nM (Ki) |
Chemical Information
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No. CAS 891198-31-5
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Appearance Solid
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Peso molecular 818.00
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Fòrmula C35H35BrClN4O10P
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Color White to off-white
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SMILES
O=P(O)(C1=CC=C(Br)C=C1)C[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)CC2=CC(C3=CC=C(C4=CC(Cl)=CC=C4)C=C3)=NO2
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Synonyms
RXP-470
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RXP470.1 Related Classifications
HY-135517 Related Classifications
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