ST7710AA1
ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC50 value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1542067-20-8
- Fòrmula: C20H22N4O
- Peso molecular:334.41
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PARP-1 0.07 μM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
2.9 μM
Compound: 1l, ST7710AA1
|
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
|
[PMID: 24398383] |
| CAPAN-1 | IC50 |
22.04 μM
Compound: 1l, ST7710AA1
|
Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
|
[PMID: 24398383] |
| HCC1937 | IC50 |
19.43 μM
Compound: 1l, ST7710AA1
|
Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
|
[PMID: 24398383] |
| HeLa | EC50 |
400 nM
Compound: 1l, ST7710AA1
|
Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
|
[PMID: 24398383] |
In Vitro
ST7710AA1 (compound 1l) (0-200 µM; 72 h) shows antiproliferative with IC50s of 19.43, 22.04 µM for HCC1937, Capan 1, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1542067-20-8
-
Peso molecular 334.41
-
Fòrmula C20H22N4O
-
SMILES
O=C(N1C=CC2=C1N=C(C=C2)C3=CC=C(C=C3)CN4CCCCC4)N
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ST7710AA1 Related Classifications
HY-117423 Related Classifications
Powered by Bioz