SYA16263
SYA16263 is a dopamine D2 receptor (D2R) and serotonin 1A receptor (5-HT1AR) ligand, with Ki values of 1.24 nM and 0.67 nM for D2R and 5-HT1AR, respectively. SYA16263 stabilizes the inactive conformation of D2R and 5-HT1AR via interactions with specific amino acid residues in their orthosteric binding pockets, thereby blocking downstream signal transduction. SYA16263 can be used in research related to schizophrenia and psychosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 129281-28-3
- Fòrmula: C19H24FN3
- Peso molecular:313.41
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Dopamine Receptor
MoreVer todos los productos específicos de isoformas 5-HT Receptor
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
Dopamine D2 receptor |
5-HT1AR |
In Vitro
SYA16263 (compound 36) (0.1 nM-10 μM; 90 min) exhibits specific binding activity to dopamine D2 receptors and 5-HT1A receptors in cell membrane fragments stably expressing specific receptors (including CHO, HEK T*, HET T, fibroblast), with Ki values of 1.24 nM and 0.67 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
SYA16263 (0.632-1.896 mg/kg; i.p.; single administration; 60-66 min) does not induce extrapyramidal side effects in the rat catalepsy test model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague-Dawley (male, ~6 weeks old, 133-153 g)[1]
-
Dosage:0.632, 1.264, 1.896 mg/kg
-
Administration:i.p.; single administration; 60, 63, 66 min
-
Result:Did not induce extrapyramidal side effects
Chemical Information
-
No. CAS 129281-28-3
-
Peso molecular 313.41
-
Fòrmula C19H24FN3
-
SMILES
FC(C=C1)=CC=C1CCCCN(CC2)CCN2C3=CC=CC=N3
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYA16263 Related Classifications
HY-187536 Related Classifications
Powered by Bioz