TP0628103
TP0628103 is a potent and highly selective MMP-7 inhibitor with an IC50 of 0.17 nM. TP0628103 undergoes structural optimization via molecular isoelectric point shifting, which reduces organic anion transporter (OAT)-mediated clearance, while maintaining potent MMP-7 inhibitory activity and enhancing MMP subtype selectivity. TP0628103 is applicable for research on the regulatory mechanisms of MMP-7-related matrix metalloproteinases.
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- No. CAS: 2865102-08-3
- Fòrmula: C51H67ClF3N11O11S
- Peso molecular:1134.66
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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MMP-7 0.17 nM (IC50) |
TP0628103 (compound 18) is a highly potent and selective human MMP-7 inhibitor, which exhibits only weak activity against human MMP-12 and MMP-14, and no significant activity against human MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 or MMP-13. Moreover, it does not induce significant off-target effects at a concentration of 10 μM in human binding, enzymatic and uptake assays, or at a concentration of 1 μM in human absorption assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2865102-08-3
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Peso molecular 1134.66
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Fòrmula C51H67ClF3N11O11S
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SMILES
CC(C)([C@@H](C(NC1=CC=C(C(N2CCC(C(N[C@@H](C(N3CC[C@@H](C3)N)=O)CCCCN)=O)CC2)=O)C=C1)=O)NC([C@@H](NC(CNC(CC[C@@H](C(O)=O)NS(=O)(C4=CC(C(F)(F)F)=C(Cl)C=C4)=O)=O)=O)CC5=CC=NC=C5)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TP0628103 Related Classifications
HY-161169 Related Classifications
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