XQ2
XQ2 is a resveratrol (HY-16561) derivative and latency-reversing agent. XQ2 releases positive transcription elongation factor b (P-TEFb) from BRD4, thereby promoting Tat-dependent viral transcription. XQ2 reactivates latent HIV-1 via activating P-TEFb.
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- Fòrmula: C17H18N2O5
- Peso molecular:330.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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HIV-1 |
BRD4 |
XQ2 (10-80 μM; 24-72 h) dose- and time-dependently reactivates latent HIV-1 in J-Lat 10.6 cells[1].
XQ2 (10-80 μM; 24-72 h) dose-dependently and time-dependently activates latent HIV-1 in J-Lat A2 cells[1].
XQ2 (40 μM; 48 h) downregulates the cell surface expression levels of HIV-1 receptor CD4 and coreceptors CXCR4 and CCR5 in human peripheral blood mononuclear cells (PBMCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ACH2 cells
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Concentration:10-100 μM (48 h dose-response); 40 μM (24-72 h time-response)
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Incubation Time:48 h (10-100 μM dose-response); 24, 48, 72 h (40 μM time-response)
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Result:Dose-dependently increased supernatant p24 levels at 10, 20, 40, 60, 100 μM for 48 h, with highly significant increases at all tested concentrations compared to resveratrol.
Time-dependently increased supernatant p24 levels at 40 μM for 24, 48, 72 h, with a dramatic increase observed at 72 h compared to resveratrol.
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Cell Line:ACH2 cells
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Concentration:5-40 μM (48 h dose-response); 40 μM (24-72 h time-response)
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Incubation Time:48 h (5-40 μM dose-response); 24, 48, 72 h (40 μM time-response)
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Result:Dose-dependently increased mRNA expression of HIV-1 genes LTR, Vpr, Vif, Tat, and Gag at 5, 10, 20, 40 μM for 48 h, with significant increases at all tested concentrations compared to the blank control.
Time-dependently increased mRNA expression of all tested HIV-1 genes at 40 μM for 24, 48, 72 h, with significant increases observed at 24, 48, 72 h compared to the 0 h control.
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Cell Line:ACH2 cells
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Concentration:5-100 μM
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Incubation Time:48 h
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Result:Weakly increased acetyl-H3K9 and acetyl-H3K14 levels at 5-100 μM for 48 h.
Reduced p-HSF1 (Ser320) levels in a dose-dependent manner at 5-100 μM for 48 h.
Chemical Information
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Peso molecular 330.34
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Fòrmula C17H18N2O5
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SMILES
O=C1NC(C2=CC=C(COCC)O2)=NC3=C1C(OC)=CC(OC)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XQ2 Related Classifications
HY-181831 Related Classifications
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