Faah - fatty acid amide hydrolase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100911581

About Faah

Primary_assembly 5: 129,479,824-129,498,677 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 6 phenotypes. Biased expression in Liver (RPKM 24.3), Brain (RPKM 57.9) and 6 other tissues.

Summary

Enables several functions, including acylglycerol Lipase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and identical protein binding activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Faah Products (1)

mRNA Protein Name
NM_001369126.1 NP_001356055.1 fatty-acid amide hydrolase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amidase activity IDA
IDA: Inferred from direct assay
12734197 RGD
enables fatty acid amide hydrolase activity IDA
IDA: Inferred from direct assay
9122178 RGD
enables fatty acid amide hydrolase activity IMP
IMP: Inferred from mutant phenotype
17545313 RGD
enables hydrolase activity, acting on ester bonds IDA
IDA: Inferred from direct assay
12734197 RGD
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
17158103 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12459591 RGD
enables lipid binding IDA
IDA: Inferred from direct assay
12734197 RGD
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
17649977 RGD
enables phospholipid binding IMP
IMP: Inferred from mutant phenotype
17158103 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
27191843 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid catabolic process IDA
IDA: Inferred from direct assay
9122178 RGD
involved in fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
17545313 RGD
involved in monoacylglycerol catabolic process IDA
IDA: Inferred from direct assay
17649977 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17245358 RGD
Cellular Component GO Annotation Evidence References Source
located in organelle membrane IDA
IDA: Inferred from direct assay
9122178 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15233753 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
15233753 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Faah Protein Structure

Amidase

Amidase: cl18951 (94 - 561)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

fatty-acid amide hydrolase 1

  • anandamide amidase

  • anandamide amidohydrolase 1

  • fatty acid ester hydrolase

  • oleamide hydrolase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1227 Carprofen Inhibitor 99.94% Unkown
HY-B0182 Carmofur Inhibitor 99.95% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-14376 Redafamdastat Inhibitor 98.86% Phase 2
HY-177093 Irafamdastat Inhibitor 98.07% Phase 2
HY-123863 SSR411298 Inhibitor 99.75% Phase 2
HY-124744 ASP 8477 Inhibitor 98.35% Phase 2
HY-19636A JNJ-42165279 dihydrochloride Inhibitor / Phase 2
HY-10864 URB-597 Inhibitor 98.53% Phase 1

Pre-clinical Phase

Bioactive Molecules (86)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14595 Biochanin A Inhibitor 99.33% Unkown
HY-119283 CAY10499 Inhibitor 99.58% Unkown
HY-136924 FP-Biotin 99.08% Unkown
HY-14380 PF-3845 Inhibitor 99.95% Unkown
HY-15250 JZL195 Inhibitor 99.75% Unkown
HY-32952 2-Fluoropyridine-5-boronic acid Inhibitor 99.99% Unkown
HY-10865 LY2183240 Inhibitor 98.04% Unkown
HY-120961 Oleoyl ethyl amide Inhibitor 99.9% Unkown
HY-116477 URB937 Inhibitor 99.62% Unkown
HY-19636 JNJ-42165279 Inhibitor 99.95% Unkown
HY-155773 VU534 Inhibitor 98.10% Unkown
HY-N2365 Macamide B Inhibitor 99.35% Unkown
HY-19740 BIA 10-2474 Inhibitor 98.74% Unkown
HY-164495 Sob-AM2 98.5% Unkown
HY-103462 TC-F2 Inhibitor 99.35% Unkown
HY-N7062 JNJ-1661010 Inhibitor 99.77% Unkown
HY-125967 AM 374 Inhibitor 97.0% Unkown
HY-N2512 1-Monomyristin Inhibitor 98.0% Unkown
HY-163733 AKU-005 Inhibitor 99.48% Unkown
HY-131678 Palmitoyl serotonin Antagonist 99.9% Unkown
HY-18081 PF 750 Inhibitor 98.99% Unkown
HY-79511 FAAH-IN-2 Inhibitor 99.12% Unkown
HY-10862 FAAH inhibitor 1 Inhibitor 98.30% Unkown
HY-77491 FAAH/MAGL-IN-5 Inhibitor 94.16% Unkown
HY-N2428 N-(3-Methoxybenzyl)Palmitamide Inhibitor 99.90% Unkown
HY-103461 FAAH-IN-6 Inhibitor 99.70% Unkown
HY-110138 PDP-EA Activator 98.28% Unkown
HY-18544 AA38-3 Inhibitor 99.95% Unkown
HY-118158 FAAH/MAGL-IN-4 Inhibitor 99.83% Unkown
HY-103337 N-Arachidonoylserotonin Inhibitor 99.11% Unkown
HY-W751418 N-Nervonoyl taurine 99.0% Unkown
HY-111389 FAAH-IN-1 Inhibitor 99.59% Unkown
HY-152254 CB2R/FAAH modulator-3 Inhibitor 99.71% Unkown
HY-N3033 N-​Benzyllinolenamide Inhibitor 99.70% Unkown
HY-18080 SA 47 Inhibitor 99.0% Unkown
HY-18013 JNJ-40355003 Inhibitor 99.81% Unkown
HY-121558 JP104 Inhibitor 99.67% Unkown
HY-14595R Biochanin A (Standard) Inhibitor 98.74% Unkown
HY-111199 JP83 Inhibitor 99.0% Unkown
HY-103339 VDM11 Inhibitor 99.25% Unkown
HY-127023 Eicosapentaenoyl serotonin Inhibitor 99.0% Unkown
HY-148909 Isopropyl dodec-11-enylfluorophosphonate Inhibitor / Unkown
HY-B1227S1 Carprofen-13C,d3 / Unkown
HY-138693 ST4070 Inhibitor / Unkown
HY-151919 FAAH-IN-7 Inhibitor / Unkown
HY-149654 FAAH/cPLA2α-IN-1 Inhibitor / Unkown
HY-10867 PF-622 Inhibitor / Unkown
HY-122159 MDPD Activator / Unkown
HY-115004 MM-433593 / Unkown
HY-152251 CB2R/FAAH modulator-1 Inhibitor 99.14% Unkown
HY-W728451 URB694 Inhibitor / Unkown
HY-116710 3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone Inhibitor / Unkown
HY-116798 URB524 Inhibitor / Unkown
HY-139143 WWL154 Inhibitor 98.96% Unkown
HY-147910 Carpro-AM1 Inhibitor / Unkown
HY-175816 5-HT6R/FAAH modulator 1 Inhibitor / Unkown
HY-144738 Dual FAAH/sEH-IN-1 Inhibitor / Unkown
HY-184331 FAAH-IN-10 Inhibitor / Unkown
HY-182589 SRP-001 Inhibitor / Unkown
HY-102054 Acetylhydrolase-IN-1 Inhibitor / Unkown
HY-B1227S Carprofen-d3 Inhibitor / Unkown
HY-120369 URB532 Inhibitor / Unkown
HY-146342 FAAH/MAGL-IN-3 Inhibitor / Unkown
HY-146341 FAAH-IN-5 Inhibitor / Unkown
HY-152253 CB2R/FAAH modulator-2 Inhibitor / Unkown
HY-103463 SA57 Inhibitor ≥99.0% Unkown
HY-143264 FAAH/MAGL-IN-2 Inhibitor / Unkown
HY-168563 BuChE-IN-15 Inhibitor / Unkown
HY-183805 5-HT6R/FAAH modulator 2 Inhibitor / Unkown
HY-143263 FAAH/MAGL-IN-1 Inhibitor / Unkown
HY-157766 FAAH/TRPV1 blocker-1 Inhibitor / Unkown
HY-12909 MK-4409 Inhibitor / Unkown
HY-169603 AZ513 Inhibitor / Unkown
HY-158784 Arachidonoyl m-nitroaniline / Unkown
HY-181463 20-Hydroxy-N-arachidonoyl taurine Substrate / Unkown
HY-164506 NRMA-8 Modulator / Unkown
HY-120650 CAY10435 Inhibitor / Unkown
HY-10869 OL-135 Inhibitor / Unkown
HY-111293 Arachidonamide / Unkown
HY-118210 PHOP Inhibitor / Unkown
HY-139384 FAAH inhibitor 2 Inhibitor 99.44% Unkown
HY-157132 FAAH-IN-8 Inhibitor / Unkown
HY-120481 JNJ-40413269 Inhibitor / Unkown
HY-161965 MK-3168 (12C) Inhibitor / Unkown
HY-121090 FAAH-IN-9 Inhibitor / Unkown
HY-U00240 SA72 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Faah NCBI NCBI:2166