Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

Also Known as ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11546

About Parp2

Chromosome 14: 51,045,298-51,058,758 forward strand.GRCm39:CM001007.3

This gene has 8 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 2.7), liver E14 (RPKM 15.1) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 Products (1)

mRNA Protein Name
NM_009632.3 NP_033762.1 poly [ADP-ribose] polymerase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
10364231 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11948190 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within base-excision repair IMP
IMP: Inferred from mutant phenotype
11948190 MGI
involved in decidualization IMP
IMP: Inferred from mutant phenotype
34580230 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12065591 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
15615785 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
15615785 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12065591 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp2 Protein Structure

PLN03124

PLN03124: cl33640 (26 - 554)

  • 0
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  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 2

  • ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2

  • ADP-ribosyltransferase (NAD+

  • poly (ADP-ribose) polymerase) 2

  • ADP-ribosyltransferase diphtheria toxin-like 2

  • DNA ADP-ribosyltransferase PARP2

  • NAD(+) ADP-ribosyltransferase 2

  • poly[ADP-ribose] synthase 2

  • poly[ADP-ribose] synthetase 2

  • protein poly-ADP-ribosyltransferase PARP2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10162 Olaparib Inhibitor 99.98% Yes
HY-16106 Talazoparib Inhibitor 99.89% Unkown
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-132167 Saruparib Inhibitor 99.76% Phase 3
HY-10129 Veliparib Inhibitor 99.77% Phase 3
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-137457 Venadaparib Inhibitor 98.52% Phase 2
HY-145584 Nesuparib Inhibitor 99.54% Phase 2
HY-122661 Mefuparib hydrochloride Inhibitor 98.62% Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1
HY-13536 AZD-2461 Inhibitor 99.79% Phase 1
HY-115552 Simmiparib Inhibitor 99.01% Phase 1
HY-170432 PARP1-IN-34 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-13688A PJ34 Inhibitor 99.66% Unkown
HY-13990 NVP-TNKS656 Inhibitor 99.68% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-14478 UPF 1069 Inhibitor 99.02% Unkown
HY-13688 PJ34 hydrochloride Inhibitor 99.81% Unkown
HY-100225 ME0328 Inhibitor 99.64% Unkown
HY-75706 N-Descyclopropanecarbaldehyde Olaparib Inhibitor 99.46% Unkown
HY-10130 Veliparib dihydrochloride Inhibitor 99.98% Yes
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-108632 BYK204165 Inhibitor 99.89% Unkown
HY-18954 NMS-P118 Inhibitor 99.54% Unkown
HY-156419 PARP7-IN-16 Inhibitor 99.91% Unkown
HY-156419A PARP7-IN-16 free base Inhibitor 99.40% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% Unkown
HY-149800 PARP-1-IN-3 Inhibitor 99.80% Unkown
HY-10614 A-966492 Inhibitor 99.00% Unkown
HY-145749 PARPYnD Inhibitor 98.86% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.40% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-183013 PROTAC PARP2 degrader-1 Degrader 95.86% Unkown
HY-105692 DR2313 Inhibitor 99.66% Unkown
HY-185459 PCIP-1 Inhibitor 98.80% Unkown
HY-102035 PARP-2-IN-1 Inhibitor 99.56% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor 98.66% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-176713 KWZY-11 Inhibitor / Unkown
HY-130646 iVeliparib-AP6 Degrader / Unkown
HY-137457A Venadaparib hydrochloride Inhibitor / Unkown
HY-132297 PARP1-IN-5 Inhibitor / Unkown
HY-145584A Nesuparib hydrochloride Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-105253 PARP-2/1-IN-2 Inhibitor / Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-168851 PARP1-IN-35 Inhibitor / Unkown
HY-181928 PARP1/c-Met-IN-3 Inhibitor / Unkown
HY-180809 YCH3292 Inhibitor / Unkown
HY-179406 PARP1-IN-49 Inhibitor / Unkown
HY-161606 PARP-1/2/7-IN-1 Inhibitor / Unkown
HY-151625 PARP-2-IN-3 Inhibitor / Unkown
HY-181265 PARP1-IN-53 Inhibitor / Unkown
HY-179386 PARP1/EZH2-IN-1 Inhibitor / Unkown
HY-179020 PARP/VEGFR3-IN-1 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-171543 PARP1-IN-37 Inhibitor / Unkown
HY-178032 PARP1-IN-44 Inhibitor / Unkown
HY-179349 PARP-1/2-IN-5 Inhibitor / Unkown
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / Unkown
HY-182246 MC2050 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-14477 UPF-1035 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp2 NCBI NCBI:10038