2. Gene
  3. Bcl2l1 - BCL2-like 1 Gene

Bcl2l1 - BCL2-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1

Gene ID: 12048 | Gene type: protein coding

About Bcl2l1

Chromosome 2: 152,622,588-152,673,648 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 285 orthologues, 10 paralogues and is associated with 20 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues.

Summary

This gene encodes a member of the Bcl-2 Family of Apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Bcl2l1 Products(5)

mRNA Protein Name
NM_001289717.1 NP_001276646.1 bcl-2-like protein 1 isoform a
NM_001289739.1 NP_001276668.1 bcl-2-like protein 1 isoform b
NM_001355053.1 NP_001341982.1 bcl-2-like protein 1 isoform a
NM_009743.5 NP_033873.3 bcl-2-like protein 1 isoform a
NM_001289716.1 NP_001276645.1 bcl-2-like protein 1 isoform a

Bcl2l1 Protein Structure

bcl-2

bcl-2: TIGR00865 (0 - 232)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 1

B-cell leukemia/lymphoma x

anti-apoptosis regulatory protein

apoptosis regulator Bcl-X

Recombinant Bcl2l1 Proteins

Cat. No. Product Name Accession Purity
HY-P72846 Bcl-XL Protein, Mouse (His) Q64373-1 (M1-R212) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-10969 Obatoclax Mesylate 99.74% Phase 3
HY-10969A Obatoclax / Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 98.78% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-135273 A-1211212 / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-156877 Bcl-2-IN-16 / Unkown
HY-N10481 Aviculin / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-N8579 Eugenyl benzoate / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-15191B (S)-Sabutoclax Inhibitor 95.66% Unkown
HY-19551 Apogossypolone / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l1 NCBI NCBI:598