Bcl2l1 - BCL2-like 1 Gene

Also Known as BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12048

About Bcl2l1

Chromosome 2: 152,622,588-152,673,648 reverse strand.GRCm39:CM000995.3

This gene has 9 transcripts (splice variants), 285 orthologues, 10 paralogues and is associated with 20 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues.

Summary

This gene encodes a member of the Bcl-2 Family of Apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Bcl2l1 Products (5)

mRNA Protein Name
NM_001289717.1 NP_001276646.1 bcl-2-like protein 1 isoform a
NM_001289739.1 NP_001276668.1 bcl-2-like protein 1 isoform b
NM_001355053.1 NP_001341982.1 bcl-2-like protein 1 isoform a
NM_009743.5 NP_033873.3 bcl-2-like protein 1 isoform a
NM_001289716.1 NP_001276645.1 bcl-2-like protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7650488 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within apoptotic process in bone marrow cell IMP
IMP: Inferred from mutant phenotype
10618441 MGI
acts upstream of or within cellular response to alkaloid IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
15231831 MGI
acts upstream of or within cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
15231831 MGI
acts upstream of dendritic cell apoptotic process IDA
IDA: Inferred from direct assay
17267035 MGI
acts upstream of dendritic cell proliferation IDA
IDA: Inferred from direct assay
17267035 MGI
acts upstream of ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: Inferred from direct assay
9176392 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
12115603 MGI
acts upstream of or within fertilization IGI
IGI: Inferred from genetic interaction
10894153 MGI
acts upstream of or within germ cell development IGI
IGI: Inferred from genetic interaction
10894153 MGI
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
10618441 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10618441 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
14517295 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within mitochondrion organization IGI
IGI: Inferred from genetic interaction
20671748 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
9867803 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
8798452 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within negative regulation of dendritic cell apoptotic process IDA
IDA: Inferred from direct assay
17267035 MGI
acts upstream of or within negative regulation of developmental process IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
7753802 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
9096145 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11150333 MGI
acts upstream of or within negative regulation of reproductive process IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of neuron apoptotic process IDA
IDA: Inferred from direct assay
7753802 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
9096145 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10618441 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11150333 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10618441 MGI
acts upstream of or within ovarian follicle development IGI
IGI: Inferred from genetic interaction
10894153 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within positive regulation of mononuclear cell proliferation IDA
IDA: Inferred from direct assay
17267035 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
10894153 MGI
acts upstream of or within release of cytochrome c from mitochondria IGI
IGI: Inferred from genetic interaction
17052454 MGI
acts upstream of or within response to cycloheximide IDA
IDA: Inferred from direct assay
9176392 MGI
acts upstream of or within response to radiation IMP
IMP: Inferred from mutant phenotype
14517295 MGI
acts upstream of or within response to virus IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10894153 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11980919 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26582200 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
11146504 MGI
located in membrane IDA
IDA: Inferred from direct assay
26582200 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
11980919 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
23530063 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
7607090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l1 Protein Structure

bcl-2

bcl-2: TIGR00865 (0 - 232)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 1

  • B-cell leukemia/lymphoma x

  • anti-apoptosis regulatory protein

  • apoptosis regulator Bcl-X

Recombinant Bcl2l1 Proteins

Cat. No. Product Name Accession Purity
HY-P72846 Bcl-XL Protein, Mouse (His, solution) Q64373-1 (M1-R212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0420A Moroxydine hydrochloride Inhibitor 99.36% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N1423 Glycocholic acid 99.90% Phase 3
HY-10969 Obatoclax Mesylate 99.85% Phase 3
HY-10969A Obatoclax ≥99.0% Phase 3
HY-15464 (R)-(-)-Gossypol 99.37% Phase 2
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1423A Glycocholic acid sodium 97.0% Unkown
HY-N1423S Glycocholic acid-d4 99.92% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-W013105 Sodium glycocholate hydrate, 98% 99.91% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-N1423B Glycocholic acid hydrate 99.85% Unkown
HY-135273 A-1211212 98.43% Unkown
HY-19551 Apogossypolone 98.58% Unkown
HY-N1423S1 Glycocholic acid-d5 99.9% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-114310 VDR agonist 1 / Unkown
HY-123715 Anticancer agent 255 / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-161415 BCL-xL/BCL-2 ligand 1 / Unkown
HY-169083 Bcl-2-IN-22 Inhibitor / Unkown
HY-174338 GPER/Bcl-2-IN-1 Inhibitor / Unkown
HY-174403 c-MYC/BCL2 ligand 1 iodide / Unkown
HY-174404 Topoisomerase II inhibitor 23 / Unkown
HY-178910 Mcl-1-IN-20 / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-181746 Bcl-2/Mcl-1-IN-5 / Unkown
HY-183369 VEGFR/PD-L1-IN-1 / Unkown
HY-N20627 Withametelin B / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-W016937 Moroxydine Inhibitor / Unkown
HY-W713297 Moroxydine hydrochloride-d8 Inhibitor / Unkown
HY-W754548 Glycocholic acid-13C2,d4 / Unkown
HY-12011A (Rac)-HA14-1 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-N6926 1,3,5-Tricaffeoylquinic acid / Unkown
HY-N8579 Eugenyl benzoate ≥90.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l1 NCBI NCBI:598