Eif4e - eukaryotic translation initiation factor 4E Gene

Also Known as If4e; eIF-4E; EG668879; Eif4e-ps

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13684

Summary

This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on Other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Eif4e Products (2)

mRNA Protein Name
NM_001313980.1 NP_001300909.1 eukaryotic translation initiation factor 4E isoform 2
NM_007917.4 NP_031943.3 eukaryotic translation initiation factor 4E isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA cap binding IDA
IDA: Inferred from direct assay
11500381 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11500381 MGI
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
16289705 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral fear response IGI
IGI: Inferred from genetic interaction
24990923 MGI
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17556672 MGI
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
8577715 MGI
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
11500381 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
acts upstream of or within negative regulation of translation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
involved in nuclear export IDA
IDA: Inferred from direct assay
15574771 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
23263185 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
23263185 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
23263185 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: Inferred from genetic interaction
25456498 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
25456498 MGI
acts upstream of translation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
involved in translational initiation IMP
IMP: Inferred from mutant phenotype
8577715 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatoid body IDA
IDA: Inferred from direct assay
22792342 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12388085 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11980711 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
11980711 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23263185 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
11500381 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
11980711 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
11980711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E

  • eIF-4F 25 kDa subunit

  • mRNA cap-binding protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100022 Tomivosertib Inhibitor 99.92% Phase 2
HY-16366 Briciclib 99.45% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19831 4EGI-1 98.69% Unkown
HY-145974A m7GpppAmpG ammonium solution (100 mM) 99.96% Unkown
HY-14427 4E1RCat Inhibitor 99.04% Unkown
HY-159059 Ganoderma Lucidum/Reishi Extract 41.20% Unkown
HY-145262 eIF4E-IN-2 Inhibitor 98.91% Unkown
HY-145969A β-S-ARCA triammonium 99.48% Unkown
HY-100733 4E2RCat Inhibitor 98.0% Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-19831A (Z)-4EGI-1 Inhibitor 98.0% Unkown
HY-176428 PROTAC MNK1 degrader-1 98.93% Unkown
HY-146805 EB1 99.91% Unkown
HY-RS04274 EIF4E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114267 Cbz-B3A Inhibitor 98.63% Unkown
HY-148105 DS12881479 99.63% Unkown
HY-145309 eIF4E-IN-3 Inhibitor / Unkown
HY-145969 β-S-ARCA / Unkown
HY-139098A 7-Methyl-diguanosine triphosphate ammonium solution (100 mM) 98.83% Unkown
HY-178672A ARCA triammonium solution (100 mM) / Unkown
HY-100022A Tomivosertib hydrochloride Inhibitor / Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-145974AGL m7GpppAmpG ammonium solution (100 mM) (GMP like) / Unkown
HY-148664 eIF4E-IN-4 Inhibitor / Unkown
HY-155337 eIF4E-IN-6 Inhibitor / Unkown
HY-155676 eIF4E-IN-5 Inhibitor / Unkown
HY-163479 MNK1/2-IN-7 Inhibitor / Unkown
HY-16366A Briciclib sodium / Unkown
HY-176288 eIF4E/eIF4G PPI-IN-1 / Unkown
HY-182046 HD202A / Unkown
HY-182939 MNK1/2-IN-10 Inhibitor / Unkown
HY-182957 MNK/PIM-IN-2 / Unkown
HY-184004 NUCC-0231068 Inhibitor / Unkown
HY-RS04275 EIF4E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W846144 ETP-45835 Inhibitor / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-139098 7-Methyl-diguanosine triphosphate / Unkown
HY-145974 m7GpppAmpG / Unkown
HY-145976 m7GpppGpG / Unkown
HY-168326 Antiproliferative agent-64 Inhibitor / Unkown
HY-172457 NUCC-0200808 Inhibitor / Unkown
HY-182704 SBI-5844 Inhibitor / Unkown
HY-RS17829 Eif4e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24297 Eif4e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4e NCBI NCBI:1977