2. Gene
  3. Myd88 - myeloid differentiation primary response gene 88 Gene

Myd88 - myeloid differentiation primary response gene 88 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 17874 | Gene type: protein coding

About Myd88

Chromosome 9: 119,165,000-119,170,477 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 86 phenotypes. Ubiquitous expression in lung adult (RPKM 14.9), spleen adult (RPKM 14.1) and 28 other tissues.

Summary

Enables Toll-like Receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products(1)

mRNA Protein Name
NM_010851.3 NP_034981.1 myeloid differentiation primary response protein MyD88

Myd88 Protein Structure

Death_MyD88

Death_MyD88: cd08312 (28 - 105)

TIR

TIR: smart00255 (160 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

myeloid differentiation primary response protein MyD88

myeloid differentiation primary response protein 88

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139397 TJ-M2010-5 Inhibitor 99.25% Unkown
HY-50937 ST 2825 Inhibitor 99.42% Unkown
HY-110204 Heclin 99.80% Unkown
HY-N0703 Schaftoside Inhibitor 99.67% Unkown
HY-110195 Smurf1-IN-A01 99.90% Unkown
HY-149992 MyD88-IN-1 Inhibitor 99.95% Unkown
HY-18976 UF010 99.84% Unkown
HY-W011400 TLR1 ≥99.0% Unkown
HY-Y0278 Chloranil Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myd88 NCBI NCBI:4615