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Myd88 - myeloid differentiation primary response gene 88 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17874

About Myd88

Chromosome 9: 119,165,000-119,170,477 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 86 phenotypes. Ubiquitous expression in lung adult (RPKM 14.9), spleen adult (RPKM 14.1) and 28 other tissues.

Summary

Enables Toll-like Receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products (1)

mRNA	Protein	Name
NM_010851.3	NP_034981.1	myeloid differentiation primary response protein MyD88

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent histone chaperone activity	IMP IMP: Inferred from mutant phenotype	18319258	MGI
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	25848864	MGI
enables interleukin-1 receptor binding	IDA IDA: Inferred from direct assay	10854325	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10854325	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16236719	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within MyD88-dependent toll-like receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12719478	MGI
acts upstream of or within MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12719478	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17660297	MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	20037584	MGI
acts upstream of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	18319258	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11067888	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	17635956	MGI
involved in defense response to protozoan	IMP IMP: Inferred from mutant phenotype	17660297	MGI
acts upstream of or within establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	22155109	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18509511	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31164412	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	15800576	MGI
acts upstream of or within induced systemic resistance	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18509511	MGI
involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	10854325	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11067888	MGI
acts upstream of or within leukocyte activation involved in inflammatory response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within microglia differentiation	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within neutrophil activation involved in immune response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within neutrophil-mediated killing of bacterium	IGI IGI: Inferred from genetic interaction	22419116	MGI
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	30883606	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19265123	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
involved in positive regulation of interleukin-23 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11067888	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within positive regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30224457	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17615359	MGI
acts upstream of or within regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17475835	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within response to molecule of fungal origin	IMP IMP: Inferred from mutant phenotype	12719478	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within response to virus	IMP IMP: Inferred from mutant phenotype	14993594	MGI
involved in skin development	IMP IMP: Inferred from mutant phenotype	31164412	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within type I interferon production	IMP IMP: Inferred from mutant phenotype	15800576	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	16751103	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16751103	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myd88 Protein Structure

Death_MyD88

TIR

0
100
200
296 a.a.

Protein Preferred Names	Protein Names
myeloid differentiation primary response protein MyD88	myeloid differentiation primary response protein 88

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112137	Trehalose-6,6'-dibehenate		99.92%	Phase 3
HY-135317	Emavusertib	Inhibitor	99.97%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99555	Tomaralimab	Inhibitor	99.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (58)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139397	TJ-M2010-5	Inhibitor	99.94%	Unkown
HY-50937	ST 2825	Inhibitor	99.92%	Unkown
HY-110204	Heclin		98.00%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.70%	Unkown
HY-Y1881B	Copper sulfate pentahydrate, for cell culture, 98%	Inhibitor	99.99%	Unkown
HY-160229	ssRNA40 sodium	Activator	98.34%	Unkown
HY-19744	T6167923	Inhibitor	99.70%	Unkown
HY-Y1881A	Copper sulfate pentahydrate, 99.9%	Inhibitor	99.90%	Unkown
HY-149992	MyD88-IN-1	Inhibitor	99.95%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-N7088	Raffinose	Inhibitor	98.0%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-18976	UF010		99.83%	Unkown
HY-N4093	Astringin	Inhibitor	99.54%	Unkown
HY-N0237	Atractyloside A	Inhibitor	98.11%	Unkown
HY-129440	N-(p-Coumaroyl) Serotonin	Inhibitor	99.03%	Unkown
HY-P10719	Pepinh-MYD	Inhibitor	99.85%	Unkown
HY-W014223	2,4′-Dihydroxybenzophenone	Inhibitor	98.00%	Unkown
HY-P10719A	Pepinh-MYD TFA	Inhibitor	98.98%	Unkown
HY-W097625	6-Methoxyflavone	Inhibitor	99.73%	Unkown
HY-170446	MyD88-IN-2	Inhibitor	99.94%	Unkown
HY-173063	TLR8 antagonist-1	Inhibitor	99.95%	Unkown
HY-N0320	Salvianolic acid D	Inhibitor	95.15%	Unkown
HY-N7653	Azaleatin	Inhibitor	98.86%	Unkown
HY-N2896	Arjunolic acid	Inhibitor	98.83%	Unkown
HY-W011400	TLR1		99.43%	Unkown
HY-178136	MyD88-IN-3	Inhibitor	99.33%	Unkown
HY-164670	D228	Inhibitor	99.77%	Unkown
HY-NP134	Flagellin from S. typhimurium	Activator	95%	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-RS08886	MYD88 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-N3979	Grossamide	Inhibitor	98.0%	Unkown
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Unkown
HY-180336	LM9	Inhibitor	/	Unkown
HY-173309	P53/TLR2 modulator-1	Inducer	/	Unkown
HY-184470	MyD88 degrader-1	Degrader	/	Unkown
HY-179047	SMU-L11-R	Activator	/	Unkown
HY-107272	Chuanbeinone	Inhibitor	/	Unkown
HY-N19847	LYRM03	Inhibitor	/	Unkown
HY-180580	SMU-C409	Activator	/	Unkown
HY-184654	MR-39	Inhibitor	/	Unkown
HY-P11913	Antimicrobial Peptide YD	Inhibitor	/	Unkown
HY-163775	Anti-inflammatory agent 88	Agonist	/	Unkown
HY-178690	MyD88-IN-4	Inhibitor	/	Unkown
HY-RS08887	Myd88 Mouse Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-155801	CRX 527	Activator	/	Unkown
HY-125447	Artemisinin B	Inhibitor	/	Unkown
HY-RS08888	Myd88 Rat Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-P5762A	Phoenixin-14 TFA	Inhibitor	/	Unkown
HY-183400	BIM-46174	Inhibitor	/	Unkown
HY-N9164	Hecubine	Inhibitor	/	Unkown
HY-135317F	Emavusertib phosphate	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate	Inhibitor	/	Unkown
HY-135317E	Emavusertib maleate	Inhibitor	/	Unkown
HY-175637	COX-2-IN-57	Inhibitor	/	Unkown
HY-135317D	Emavusertib mesylate	Inhibitor	/	Unkown
HY-Y0278R	Chloranil (Standard)	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myd88	NCBI	NCBI:4615