CYS1 - cystin 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 192668

About CYS1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,056,473-10,080,411 (from NCBI)

This gene has 2 transcripts (splice variants) and 45 orthologues. Biased expression in kidney (RPKM 77.2), ovary (RPKM 7.7) and 4 other tissues.

Summary

Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to act upstream of or within animal organ development and regulation of transcription, DNA-templated. Predicted to be located in cytoskeleton; membrane raft; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CYS1 Products (1)

mRNA Protein Name
NM_001037160.3 NP_001032237.1 cystin-1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22085962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystin-1

  • cilia-associated protein

Related Diseases

Diseases Alias
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

  • Autosomal Recessive Polycystic Kidney Disease

  • Arpkd

  • Polycystic Kidney Disease, Autosomal Recessive

  • Polycystic Kidney And Hepatic Disease 1

  • Pkhd1

  • PKD4

  • Polycystic Kidney Disease 4 With Or Without Hepatic Disease

  • Polycystic Kidney Disease, Infantile, Type I

  • Polycystic Kidney Disease, Infantile Type

  • Polycystic Kidney, Autosomal Recessive

  • Pkd3, Formerly

  • Polycystic Kidney Disease 4, With Or Without Hepatic Disease

  • Arpkd/Chf

  • Ar-Pkd

  • Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

  • Infantile Polycystic Kidney Disease Type I

  • Pkd3

  • Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

  • Polycystic Kidney Disease 3, Autosomal Dominant
Spinocerebellar Ataxia 14

  • Spinocerebellar Ataxia Type 14

  • SCA14

  • Ataxia, Spinocerebellar, Type 14
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Cystic Kidney Disease

  • Renal Cyst

  • Simple Renal Cyst

  • Kidney Cysts

  • Kidney Diseases, Cystic

  • Renal Cysts

  • Kidney Cyst

  • Cystic Kidney

  • Congenital Cystic Kidney Disease

  • Cystic Kidney Diseases

  • Bosniak 1 Cyst
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0090 Calcitonin (salmon) Agonist 99.96% Unkown
HY-B1811 Vasopressin 99.65% Yes
HY-P0049 Argipressin Agonist 98.71% Unkown
HY-P0004 Lysipressin Activator 99.22% Unkown
HY-A0182 Felypressin Agonist 99.74% Unkown
HY-P0083 Ornipressin Agonist 99.87% Unkown
HY-17584A Linaclotide acetate Agonist 98.75% Unkown
HY-P0049A Argipressin diacetate / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-W539944 Argipressin acetate 99.16% Phase 4
HY-A0182A Felypressin acetate Agonist 98.90% Phase 4
HY-P5533 CRT 99.76% Phase 4
HY-P3448 Certepetide Activator 99.80% Phase 2
HY-106302 Duramycin 99.72% Phase 2

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0202 Endothelin 1 (swine, human) Activator 99.12% Unkown
HY-P0256 Apamin Inhibitor 99.96% Unkown
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA 99.57% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-P0202A Endothelin 1 (swine, human) TFA 99.77% Unkown
HY-P5322 Thrombospondin (TSP-1)-derived CD36 binding motif 99.58% Unkown
HY-P1408 Obtustatin 99.94% Unkown
HY-P1206 CH 275 Agonist 99.52% Unkown
HY-P1408A Obtustatin triacetate Inhibitor 99.97% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-P3561A Agouti-related Protein (AGRP) (83-132) Amide (human) TFA Inhibitor 96.96% Unkown
HY-P2526 LyP-1 99.68% Unkown
HY-P11474 FZ1 peptide 99.92% Unkown
HY-P0207A Endothelin-2 (49-69), human TFA Ligand 99.21% Unkown
HY-P0204 Endothelin-3, human, mouse, rabbit, rat 97.58% Unkown
HY-17571F Biotin-Oxytocin 99.95% Unkown
HY-P10235 Cyclic AC253 Antagonist 99.83% Unkown
HY-P10557 DAG peptide 99.88% Unkown
HY-P4605A (Ile8)-Oxytocin acetate 99.65% Unkown
HY-P0256A Apamin TFA Inhibitor 97.49% Unkown
HY-P11354A THR-123 TFA / Unkown
HY-P4678 (Phe2,Orn8)-Oxytocin Agonist 99.55% Unkown
HY-102029 Sarafotoxin S6c Agonist 98.19% Unkown
HY-172275A DSPE-PEG2000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8) 95.20% Unkown
HY-P10934 LXY3 Inhibitor 98.33% Unkown
HY-P10383 SPSB2-iNOS inhibitory cyclic peptide-1 99.81% Unkown
HY-P2538 Big Endothelin-1 (1-38), human Agonist 99.23% Unkown
HY-P3215 Oxytocin parallel dimer Activator 98.29% Unkown
HY-P4605 (Ile8)-Oxytocin 99.65% Unkown
HY-P0083A Ornipressin acetate Agonist 99.63% Unkown
HY-P0207 Endothelin-2 (49-69), human Ligand 99.86% Unkown
HY-P11094 Tet1-Cys peptide 99.13% Unkown
HY-P11143 IL4RPep-1 Inhibitor / Unkown
HY-P11143A IL4RPep-1 acetate 98.61% Unkown
HY-P1463 Calcitonin, eel / Unkown
HY-P1463A Calcitonin, eel TFA 99.91% Unkown
HY-P1574 [Arg8]-Vasotocin / Unkown
HY-P1574A [Arg8]-Vasotocin TFA 98.41% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.52% Unkown
HY-P3215A Oxytocin parallel dimer TFA Activator 98.10% Unkown
HY-P4205 Aminopeptidase N Ligand (CD13) NGR peptide Inhibitor 99.54% Unkown
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-P0090S Calcitonin-13C6,15N4 (salmon) TFA Agonist / Unkown
HY-172275 DSPE-PEG1000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8) / Unkown
HY-P0038 MK-852 Antagonist / Unkown
HY-P0090A Calcitonin (salmon) acetate Agonist / Unkown
HY-P10237 Calcitonin (chicken) Modulator / Unkown
HY-P10328 Vasoactive intestinal contractor Inhibitor / Unkown
HY-P10383A SPSB2-iNOS inhibitory cyclic peptide-1 TFA / Unkown
HY-P10693 CZEN-002 Inhibitor / Unkown
HY-P10698 VH-N412 / Unkown
HY-P10826 PD-1/PD-L1 inhibitory peptide C8 Inhibitor / Unkown
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / Unkown
HY-P10837 LAG-3 cyclic peptide inhibitor 12 Inhibitor / Unkown
HY-P10924 Roseltide rT1 Inhibitor / Unkown
HY-P11246 A13:B7-24-GG Agonist / Unkown
HY-P11264 Cyclic peptide P1-1 / Unkown
HY-P11354 THR-123 / Unkown
HY-P11408 [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) Agonist / Unkown
HY-P11588 KBP-042 Activator / Unkown
HY-P11610 KBP-089 Agonist / Unkown
HY-P11612 ATS-9R / Unkown
HY-P11745 CGSPGWVRC / Unkown
HY-P11762 CKGGRAKDC (Disulfide bridge: Cys1-Cys9) / Unkown
HY-P11814 cTMTP1 / Unkown
HY-P11816 DOTA-cTMTP1 / Unkown
HY-P11823 FAPα/DPP4 flurogenic substrate-1 / Unkown
HY-P11827 C11 peptide-1 Inhibitor / Unkown
HY-P1371 Pseudo RACK1 Agonist / Unkown
HY-P1372 PKC ζ pseudosubstrate Inhibitor / Unkown
HY-P1719 Recanaclotide / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2005 Malformin C / Unkown
HY-P2496 Endothelin 1 (swine, human), Alexa Fluor 488-labeled / Unkown
HY-P2539 Big Endothelin-1 (1-39), porcine Agonist / Unkown
HY-P3171 Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) / Unkown
HY-P3433 Sarafotoxin S6b Agonist / Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown
HY-P3563 [Lys4] Sarafotoxin S6c Agonist / Unkown
HY-P3565 Sarafotoxin S6d / Unkown
HY-P3571 [Ala2] Endothelin-3, human / Unkown
HY-P4320 Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge: Cys1-Cys10) Antagonist / Unkown
HY-P4678A (Phe2,Orn8)-Oxytocin acetate Agonist / Unkown
HY-P4994 Val9-Oxytocin Antagonist / Unkown
HY-P5010 (D-Arg8)-Inotocin Antagonist / Unkown
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / Unkown
HY-P5130 Big endothelin-1 (rat 1-39) Ligand / Unkown
HY-P5140 ω-Tbo-IT1 Inhibitor / Unkown
HY-P5568 Siamycin III Inhibitor / Unkown
HY-P5738 Palicourein Inhibitor / Unkown
HY-P5907 Helianorphin-19 Activator / Unkown
HY-RS03493 CYS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P3448S Certepetide-13C6,15N2 Activator / Unkown
HY-P3448S1 Certepetide-13C2,15N Activator / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYS1 RGD RGD:1596023
Mus musculus CYS1 MGD MGI:2177632