Stat6 - signal transducer and activator of transcription 6 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20852

About Stat6

Chromosome 10: 127,478,855-127,496,826 forward strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 71 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Stat6 Products (1)

mRNA Protein Name
NM_009284.2 NP_033310.2 signal transducer and transcription activator 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10490661 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16537510 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15659391 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T-helper 1 cell lineage commitment IGI
IGI: Inferred from genetic interaction
20706986 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
31408278 MGI
involved in interleukin-4-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17210636 MGI
acts upstream of isotype switching to IgE isotypes IGI
IGI: Inferred from genetic interaction
10490661 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
22588720 MGI
acts upstream of or within mammary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
22588720 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20956546 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18997793 MGI
acts upstream of or within negative regulation of type 2 immune response IGI
IGI: Inferred from genetic interaction
10438949 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24906148 MGI
acts upstream of or within positive regulation of isotype switching to IgE isotypes IGI
IGI: Inferred from genetic interaction
10490661 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9110977 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21217760 MGI
acts upstream of or within regulation of mast cell proliferation IDA
IDA: Inferred from direct assay
12093868 MGI
acts upstream of or within signal transduction IMP
IMP: Inferred from mutant phenotype
17658279 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
15187136 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12093868 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12093868 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat6 Protein Structure

STAT_int

STAT_int: cl03749 (1 - 114)

STAT6_CCD

STAT6_CCD: cd16856 (104 - 275)

STAT6_DBD

STAT6_DBD: cd16850 (272 - 431)

SH2_STAT6

SH2_STAT6: cd10377 (516 - 645)

STAT6_C

STAT6_C: pfam14596 (654 - 836)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 837 a.a.
Protein Preferred Names Protein Names

signal transducer and transcription activator 6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-B1076 Medrysone Modulator 99.79% Unkown
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-112961 Patiromer Inhibitor 95.0% Unkown
HY-100754A Ritlecitinib malonate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123823 Nitroaspirin Inhibitor 98.57% Phase 2
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 99.37% Phase 4
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100614 AS1517499 Inhibitor 99.17% Unkown
HY-169179 AK-1690 Degrader 99.91% Unkown
HY-113402 Gamma-glutamylcysteine Activator 98.53% Unkown
HY-134771 YM-341619 Inhibitor 98.01% Unkown
HY-158399 STAT6-IN-5 Inhibitor 99.88% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-158398 STAT6-IN-4 Inhibitor 99.77% Unkown
HY-134772 AS1810722 Inhibitor 98.10% Unkown
HY-169182 AK-068 Ligand 99.57% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-177456 STAT6 degrader-3 Degrader 99.26% Unkown
HY-176857 PROTAC STAT6 degrader-1 Degrader 99.55% Unkown
HY-117548 UNC1062 Inhibitor 98.92% Unkown
HY-N0407 Picroside I Inhibitor 99.31% Unkown
HY-176864 STAT6 ligand-1 Ligand 98.94% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-176949 STAT6-IN-10 Inhibitor 98.81% Unkown
HY-113509B 15(R)-Lipoxin A4 Inhibitor 98.3% Unkown
HY-123115 Leucrose 98.53% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-183837 PROTAC STAT6 degrader-8 Degrader / Unkown
HY-183834 PROTAC STAT6 degrader-7 Degrader / Unkown
HY-183733 STAT6 degrader-4 Degrader / Unkown
HY-162404 (14S,15R)-14-Deoxyoxacyclododecindione Inhibitor / Unkown
HY-179233 PROTAC STAT6 degrader-2 Degrader / Unkown
HY-164216 STAT6-IN-13 Inhibitor / Unkown
HY-171441 STAT6 degrader-1 Degrader / Unkown
HY-185073 STAT6-IN-11 Inhibitor / Unkown
HY-162405 STAT6-IN-12 Inhibitor / Unkown
HY-183839 PROTAC STAT6 degrader-9 Degrader / Unkown
HY-183847 PROTAC STAT6 degrader-10 Degrader / Unkown
HY-W1113771 STAT6-IN-7 Inhibitor 99.53% Unkown
HY-175650 STAT6-IN-9 Inhibitor 98.11% Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-W1113770 STAT6-IN-8 Inhibitor / Unkown
HY-182699 PROTAC STAT6 degrader-5 Degrader / Unkown
HY-181901 PROTAC STAT6 degrader-4 Degrader / Unkown
HY-164216A (trans)-STAT6-IN-13 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat6 NCBI NCBI:6778