Smo - smoothened, frizzled class receptor Gene

Also Known as Smoh

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25273

About Smo

Primary_assembly 4: 58,343,529-58,373,829 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 204 orthologues, 15 paralogues and is associated with 46 phenotypes. Biased expression in Uterus (RPKM 82.7), Kidney (RPKM 58.7) and 9 other tissues.

Summary

Predicted to enable patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Used to study Barrett's esophagus; esophagus adenocarcinoma; and middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; pre-malignant neoplasm; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo Products (1)

mRNA Protein Name
NM_012807.2 NP_036939.2 smoothened homolog precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
19447091 RGD
involved in commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
19946319 RGD
involved in facial nerve development IEP
IEP: Inferred from expression pattern
15356205 RGD
involved in mesenchymal to epithelial transition IMP
IMP: Inferred from mutant phenotype
22994359 RGD
involved in negative regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
22994359 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20848190 RGD
involved in neuron projection regeneration IEP
IEP: Inferred from expression pattern
15356205 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
19649528 RGD
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
31221056 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20600593 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
22994359 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
23696546 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
24472833 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
19484749 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
21618238 RGD
located in dendrite IDA
IDA: Inferred from direct assay
21618238 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
21618238 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15356205 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
21618238 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

smoothened homolog

  • smoothened protein

  • smoothened, frizzled family receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16582A Sonidegib Antagonist 99.98% Yes
HY-16391 Glasdegib Inhibitor 99.65% Yes
HY-B0603 Fluticasone Agonist 98.70% Yes
HY-16582 Sonidegib diphosphate Antagonist 99.97% Yes
HY-B0877 Halcinonide Agonist 98.29% Unkown
HY-16391A Glasdegib maleate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-13654 IPI-269609 Inhibitor / Phase 4
HY-16587 Saridegib Inhibitor 99.95% Phase 3
HY-13242 Taladegib Inhibitor 99.92% Phase 2
HY-13809 BMS-833923 Inhibitor 99.82% Phase 2
HY-18636 LEQ506 Inhibitor 98.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12848 SAG Agonist 99.79% Unkown
HY-17024 Cyclopamine Inhibitor 99.97% Unkown
HY-15108 Purmorphamine Activator 99.94% Unkown
HY-100224 SANT-1 Antagonist 99.87% Unkown
HY-12848B SAG hydrochloride Agonist 99.91% Unkown
HY-12848C SAG dihydrochloride Agonist 98.23% Unkown
HY-15483 DY131 Inhibitor 99.72% Unkown
HY-100535 KAAD-Cyclopamine Antagonist ≥96.0% Unkown
HY-12316 20(S)-Hydroxycholesterol Activator 99.63% Unkown
HY-15108G Purmorphamine (GMP) Agonist / Unkown
HY-12317 GSA-10 Agonist ≥98.0% Unkown
HY-13459 PF-5274857 Antagonist 99.31% Unkown
HY-15412 HhAntag 99.40% Unkown
HY-N0247 Saikosaponin B1 Inhibitor 99.42% Unkown
HY-151115 JNJ-1289 Inhibitor 98.06% Unkown
HY-12848R SAG (Standard) Agonist 99.56% Unkown
HY-137115 BODIPY-Cyclopamine 98.91% Unkown
HY-113965 CUR61414 Inhibitor ≥99.0% Unkown
HY-115566 S1PL-IN-1 Antagonist 99.90% Unkown
HY-100036 MK-4101 Antagonist 99.16% Unkown
HY-117407 ALLO-2 Antagonist 99.31% Unkown
HY-12316R 20(S)-Hydroxycholesterol (Standard) Activator 98.69% Unkown
HY-18287 MRT-83 Antagonist 99.27% Unkown
HY-18287A MRT-83 hydrochloride Antagonist 99.60% Unkown
HY-108508 SMANT hydrochloride Inhibitor 99.90% Unkown
HY-100224G SANT-1 (GMP) Antagonist / Unkown
HY-120499 AZD8542 Antagonist 99.49% Unkown
HY-145387 MRT-81 Antagonist 99.85% Unkown
HY-110240 IHR-1 Antagonist 98.05% Unkown
HY-108507 MRT-10 Antagonist 98.99% Unkown
HY-12848S SAG-d3 Inhibitor 99.85% Unkown
HY-16391S1 Glasdegib-d4 Inhibitor / Unkown
HY-150567 SMO-IN-3 Inhibitor / Unkown
HY-16391B Glasdegib hydrochloride Inhibitor / Unkown
HY-131016 IHR-Cy3 Antagonist / Unkown
HY-148440 RL-0070933 Modulator / Unkown
HY-183335 SMO-IN-6 Inhibitor / Unkown
HY-177291 LAB687 Antagonist / Unkown
HY-162372 Hedgehog IN-6 Inhibitor / Unkown
HY-147743 SMO-IN-1 Inhibitor / Unkown
HY-147744 AZD7254 Inhibitor / Unkown
HY-147670 TPB15 Inhibitor / Unkown
HY-13242A Taladegib hydrochloride Inhibitor 97.02% Unkown
HY-110326 Smo antagonist M25 Antagonist / Unkown
HY-153499 SMO-IN-4 Antagonist / Unkown
HY-162273 Antibacterial agent 189 / Unkown
HY-159893 SMO-IN-5 Inhibitor / Unkown
HY-145918 MRT-14 Antagonist 99.04% Unkown
HY-12848A (Rac)-SAG Agonist / Unkown
HY-13459A PF-5274857 hydrochloride Antagonist / Unkown
HY-123752 MS-0022 Antagonist / Unkown
HY-150564 SMO-IN-2 Inhibitor 98.12% Unkown
HY-133974 7-keto-25-Hydroxycholesterol Activator / Unkown
HY-117903A MRT-92 Antagonist / Unkown
HY-184378 MDB5 Inhibitor / Unkown
HY-W338819 Clobetasol Agonist / Unkown
HY-12848G SAG (GMP) Agonist / Unkown
HY-16587A Saridegib hydrochloride Inhibitor / Unkown
HY-W700539 N1-Acetyl triethylenetetramine Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990418 Anti-FZD7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smo NCBI NCBI:6608