Hdac10 - histone deacetylase 10 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362981

About Hdac10

Primary_assembly 7: 120,199,129-120,204,228 reverse strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 181 orthologues, 12 paralogues and is associated with 4 phenotypes. Biased expression in Muscle (RPKM 36.9), Thymus (RPKM 35.1) and 9 other tissues.

Summary

Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Involved in oligodendrocyte development. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Apr 2022]

Hdac10 Products (1)

mRNA Protein Name
NM_001035000.1 NP_001030172.1 polyamine deacetylase HDAC10

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in oligodendrocyte development IEP
IEP: Inferred from expression pattern
18627006 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac10 Protein Structure

Arginase_HDAC

Arginase_HDAC: cl17011 (17 - 353)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

polyamine deacetylase HDAC10

  • HD10

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (50)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.87% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-178948A HDAC10-IN-3 formic Inhibitor 97.16% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-174444 PROTAC HDAC degrader-2 Degrader / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-174471 HDAC-IN-90 Ligand / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac10 NCBI NCBI:83933