CASR - calcium sensing receptor Gene

Canis lupus familiaris (sub-species: familiaris)

Gene ID: 488007 | Gene type: protein coding

About CASR

Primary_assembly 33: 25,592,410-25,668,339 forward strand.ROS_Cfam_1.0:CM025132.1

This gene has 2 transcripts (splice variants), 203 orthologues and 4 paralogues.

CASR Products(1)

mRNA	Protein	Name
NM_001081509.3	NP_001074978.1	extracellular calcium-sensing receptor precursor

CASR Protein Structure

PBP1_CaSR

NCD3G

7tmC_CaSR

0
200
400
600
800
1000
1075 a.a.

Protein Preferred Names

Protein Names

extracellular calcium-sensing receptor

calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-70037	Cinacalcet	Agonist	99.93%	Yes
HY-70037A	Cinacalcet hydrochloride	Agonist	99.98%	Yes
HY-P1955A	Etelcalcetide hydrochloride	Activator	99.80%	Unkown
HY-17397	Strontium Ranelate	Activator	99.30%	Unkown
HY-17613	Evocalcet	Activator	99.28%	Unkown
HY-109106A	Upacicalcet sodium	Agonist	99.91%	Unkown
HY-P1955	Etelcalcetide	Activator	/	Unkown
HY-109106	Upacicalcet	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10007	NPS-2143	Antagonist	99.94%	Phase 2
HY-10167A	Tecalcet Hydrochloride	Modulator	99.43%	Phase 2

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139201A	Poly-D-lysine hydrobromide (MW 70000-150000)	Agonist	99.86%	Unkown
HY-139201	Poly-D-lysine hydrobromide (MW 30000-70000)	Agonist	/	Unkown
HY-112171	γ-L-Glutamyl-L-alanine	Modulator	98.0%	Unkown
HY-12557	γ-Glutamylvaline	Agonist	99.94%	Unkown
HY-10171	NPS-2143 hydrochloride	Antagonist	99.98%	Unkown
HY-103320A	Calhex 231 hydrochloride	Inhibitor	99.81%	Unkown
HY-N0546	Ligustroflavone	Antagonist	99.90%	Unkown
HY-11095	NPS 2390	Inhibitor	99.90%	Unkown
HY-139201B	Poly-D-lysine hydrobromide (MW 84000)	Agonist	/	Unkown
HY-14401	Encaleret	Antagonist	99.88%	Unkown
HY-121584	Lycoperodine-1	Agonist	99.82%	Unkown
HY-W843885	H-Glu-Thr-OH	Activator	98.63%	Unkown
HY-122819	Calindol hydrochloride	Agonist	99.64%	Unkown
HY-139201D	Poly-D-lysine hydrobromide (MW 4000-15000)		/	Unkown
HY-P4376A	Gamma-Glu-Abu TFA	Agonist	96.83%	Unkown
HY-117851	AC-265347	Agonist	99.97%	Unkown
HY-103320B	(1R,2R)-Calhex 231 hydrochloride	Control	98.45%	Unkown
HY-112171R	γ-L-Glutamyl-L-alanine (Standard)	Modulator	99.29%	Unkown
HY-50713	Calcium-Sensing receptor antagonist I	Antagonist	98.95%	Unkown
HY-107773	GSK3004774	Agonist	99.09%	Unkown
HY-139201E	Poly-D-lysine hydrobromide (MW 150000-300000)	Agonist	/	Unkown
HY-139201H	Poly-D-lysine hydrobromide (MW ≥300000)	Activator	/	Unkown
HY-15105	SB-423562	Antagonist	99.66%	Unkown
HY-15104	Ronacaleret hydrochloride	Antagonist	99.81%	Unkown
HY-70037AS	Cinacalcet-d3 hydrochloride	Agonist	97.63%	Unkown
HY-14752	Ronacaleret	Antagonist	/	Unkown
HY-153258	CaSR antagonist-1	Antagonist	/	Unkown
HY-10167	Tecalcet	Modulator	/	Unkown
HY-177303	AXT-914	Inhibitor	98.83%	Unkown
HY-P11668	Gosicalcetide	Agonist	/	Unkown
HY-109106B	(Rac)-Upacicalcet		95.0%	Unkown
HY-139201C	Poly-D-lysine hydrobromide (MW 1000-5000)	Activator	/	Unkown
HY-70037S	Cinacalcet-D3	Agonist	/	Unkown
HY-14401B	Encaleret sodium	Antagonist	/	Unkown
HY-P4376	Gamma-Glu-Abu	Agonist	/	Unkown
HY-179475	KP-2067	Agonist	/	Unkown
HY-W777503	Calindol hydrochloride-13C,D2		/	Unkown
HY-P11832	CaSR agonist peptide-1	Agonist	/	Unkown
HY-103320	Calhex 231	Antagonist	/	Unkown
HY-15106	SB-423557	Antagonist	/	Unkown
HY-17613S	Evocalcet-d4	Activator	/	Unkown
HY-182543	NPS-467	Activator	/	Unkown
HY-171446	TAK-075	Antagonist	/	Unkown
HY-161113	Z8554052021	Activator	/	Unkown
HY-W653978	Cinacalcet-d4 hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CASR	NCBI	NCBI:846

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