PGD - phosphogluconate dehydrogenase Gene

Also Known as 6PGD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5226

Summary

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Broad expression in esophagus (RPKM 163.6), bone marrow (RPKM 118.1) and 22 other tissues.

PGD Products (4)

mRNA Protein Name
NM_001304451.2 NP_001291380.1 6-phosphogluconate dehydrogenase, decarboxylating isoform 2
NM_001304452.2 NP_001291381.1 6-phosphogluconate dehydrogenase, decarboxylating isoform 3
NM_001446303.1 NP_001433232.1 6-phosphogluconate dehydrogenase, decarboxylating isoform 4
NM_002631.4 NP_002622.2 6-phosphogluconate dehydrogenase, decarboxylating isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in pentose-phosphate shunt, oxidative branch IDA
IDA: Inferred from direct assay
3858849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Recombinant PGD Proteins

Cat. No. Product Name Accession Purity
HY-P7450 PGD Protein, Human (HEK293, His) P52209-1 (M1-A483) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73376 PGD Protein, Human (His) P52209-1 (M1-A483) ≥ 85%, as determined by reducing SDS-PAGE.

PGD Antibodies

Cat. No. Product Name Application Reactivity
HY-P81982 PGD Antibody (YA1727) WB, ICC/IF, IP Human, Mouse, Rat
HY-P81982A PGD Antibody (YA1727)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0195 Tranilast Inhibitor 99.95% Yes
HY-B0157 Ketotifen Inhibitor 99.94% Yes
HY-B0157A Ketotifen fumarate Inhibitor 99.88% Yes
HY-B0745 Ramatroban Antagonist 99.23% Yes
HY-16344 Nedocromil sodium Inhibitor / Unkown
HY-B0195A Tranilast sodium Inhibitor 99.48% Yes

Clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Phase
HY-124065 ARRY-502 Antagonist / Phase 4
HY-129397 2,3-Dinor-11beta-prostaglandin F2alpha / Phase 4
HY-109134 Pizuglanstat Inhibitor 99.70% Phase 3
HY-15342 Timapiprant Antagonist 98.12% Phase 2
HY-15950 AZD1981 Antagonist 99.80% Phase 2
HY-114141 BI-671800 Antagonist 99.36% Phase 2
HY-124852 ZPL-5212372 Inhibitor / Phase 2
HY-19755 S-5751 Antagonist / Phase 2
HY-101988 Prostaglandin D2 Activator 99.5% Phase 1
HY-116449 2-Benzoylthiophene 99.90% Phase 1
HY-13213 AM211 Antagonist 98.79% Phase 1
HY-118830S 13,14-Dihydro-15-keto prostaglandin D2-d4 Agonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (86)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13988 AT-56 Inhibitor 99.75% Unkown
HY-108568 15-Deoxy-Δ-12,14-prostaglandin J2 Agonist ≥99.0% Unkown
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-N7850 6PGD-IN-1 99.48% Unkown
HY-136500 Prostaglandin H2 Activator 99.9% Unkown
HY-113366 Prostaglandin J2 Agonist 98.1% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.42% Unkown
HY-N6064 Polygalacin D 99.95% Unkown
HY-101988S Prostaglandin D2-d4 Activator 98.81% Unkown
HY-50848 BW A868C Antagonist 99.9% Unkown
HY-118830 13,14-Dihydro-15-keto prostaglandin D2 Agonist 99.90% Unkown
HY-118282 mPGES1-IN-7 Inhibitor 99.78% Unkown
HY-146877S 16:0-18:1 PG-d31 99.59% Unkown
HY-15342A Timapiprant sodium Inhibitor 99.61% Unkown
HY-N2252 Licarin A Inhibitor 99.83% Unkown
HY-U00027 Quinotolast sodium Inhibitor 98.38% Unkown
HY-13706 CAY10471 Racemate Antagonist 99.00% Unkown
HY-175492 6PGD-IN-2 Inhibitor 99.86% Unkown
HY-118816 11β-Prostaglandin F2α 95.0% Unkown
HY-118828A (9S,13R)-12-Oxo phytodienoic acid 99.0% Unkown
HY-139972 PROTAC(H-PGDS)-7 Inhibitor 99.42% Unkown
HY-101430 PGD2-IN-1 Antagonist 98.03% Unkown
HY-108568S 15-Deoxy-Δ-12,14-prostaglandin J2-d4 Agonist 98.10% Unkown
HY-110167 TFC 007 Inhibitor 98.68% Unkown
HY-125782 15(R)​-​15-​Methyl prostaglandin D2 98.0% Unkown
HY-RS10432 PHGDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10433 Phgdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101988S1 Prostaglandin D2-d9 Activator 99.9% Unkown
HY-113096 Prostaglandin D1 Activator 98.8% Unkown
HY-116028 15-deoxy-Δ12,14-Prostaglandin D2 98.0% Unkown
HY-126134 HPGDS inhibitor 2 Inhibitor 99.70% Unkown
HY-137308 15(R)-Prostaglandin D2 99.9% Unkown
HY-13988R AT-56 (Standard) Inhibitor 98.41% Unkown
HY-101235 ICI 185282 Antagonist / Unkown
HY-109134A Pizuglanstat hydrate Inhibitor / Unkown
HY-112533 11-Deoxy-11-methylene PGD2 / Unkown
HY-113096S Prostaglandin D1-d4 Activator / Unkown
HY-113264 PGD2 ethanolamide Inducer / Unkown
HY-113264S PGD2 ethanolamide-d4 / Unkown
HY-113444 Prostaglandin D3 Inhibitor / Unkown
HY-116028S1 15-deoxy-Δ12,14-Prostaglandin D2-d4 / Unkown
HY-116250 Prostaglandin D2-1-glyceryl ester Agonist / Unkown
HY-117628 RN983 Inhibitor / Unkown
HY-117659 PGDM Agonist / Unkown
HY-118828AS (9S,13R)-12-Oxo phytodienoic acid-d5 / Unkown
HY-118830S1 13,14-Dihydro-15-keto prostaglandin D2-d9 Agonist / Unkown
HY-122147 L-644698 Agonist / Unkown
HY-126081 (8-epi)-BW 245C Agonist / Unkown
HY-137288 17-Phenyl-18,19,20-trinor-PGD2 Control / Unkown
HY-137355 15(S)-15-methyl Prostaglandin D2 / Unkown
HY-145507S 1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol)-d31 ammonium / Unkown
HY-146662 HPGDS inhibitor 3 Inhibitor / Unkown
HY-146853S 17:0-14:1 PG-d5 / Unkown
HY-146854S 15:0 Lyso PG-d5 / Unkown
HY-146855S 19:0 Lyso PG-d5 / Unkown
HY-146856S 17:0 Lyso PG-d5 / Unkown
HY-146857S 17:0-22:4 PG-d5 / Unkown
HY-146858S 17:0-20:3 PG-d5 / Unkown
HY-146859S 17:0-18:1 PG-d5 / Unkown
HY-146860S 17:0-16:1 PG-d5 / Unkown
HY-146878S 16:0-18:1 PG-d5 98.0% Unkown
HY-157577 PROTAC(H-PGDS)-8 Degrader / Unkown
HY-158585 5-trans Prostaglandin D2 / Unkown
HY-160844 CT-133 / Unkown
HY-175131 Prostaglandin D2-biotin / Unkown
HY-176243 15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester Agonist / Unkown
HY-176301 Tetranor-PGDM lactone / Unkown
HY-182637 ACT-774312 Antagonist / Unkown
HY-B0745S Ramatroban-d4 Antagonist / Unkown
HY-E70559 Prostaglandin D synthase / Unkown
HY-N15483 13,14-Dihydro-15-keto prostaglandin J2 / Unkown
HY-N16372 Pronqodine A / Unkown
HY-RS11369 Ptgdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W339838S 1-Myristoyl-2-hydroxy-sn-glycero-3-PG-d27 sodium / Unkown
HY-W511185 ST026567 / Unkown
HY-120656 Prostaglandin K2 / Unkown
HY-126911 11-keto Fluprostenol / Unkown
HY-13213A AM211 sodium Antagonist / Unkown
HY-134860 Prostaglandin D1 alcohol / Unkown
HY-139171 F092 Inhibitor 99.79% Unkown
HY-165080 16,16-Dimethyl prostaglandin D2 / Unkown
HY-B0157S1 Ketotifen-d3 Inhibitor / Unkown
HY-P10226 PGD97 / Unkown
HY-RS16334 PGD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17575 Pgd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24035 Pgd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown