HDAC-IN-68
Based on 1 publication(s) in Google Scholar
HDAC-IN-68 (Compound 29) is a potent HDAC inhibitor that disrupts microtubule structure and inhibits tumor growth. HDAC-IN-68 significantly inhibits class I HDACs (HDAC1, HDAC2, HDAC3) with IC50 values of 5.1, 11.5 and 8.8 nM, respectively.
For research use only. We do not sell to patients.
- Formula: C27H24N8O6
- Molecular Weight:556.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) HDAC-IN-68
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
0.51 μM
Compound: 29
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Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
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[PMID: 38141287] |
| NCI-H1975 | IC50 |
1.2 μM
Compound: 29
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Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
|
[PMID: 38141287] |
Chemical Information
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Molecular Weight 556.53
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Formula C27H24N8O6
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SMILES
O=C(N1C2=C(OC)N=CC=C2)NC3=C1N=C(C4=CC=C(OCC)N=C4)N=C3C(NCC5=CC=C(C=C5)C(NO)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)