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Art. -Nr.: HY-173386

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HDAC6 ligand-4

HDAC6 ligand-4 is a targeted ligand for histone deacetylase 6 (HDAC6). HDAC6 ligand-4 can serve as a target protein ligand for TO-1187 (HY-173266) and is used in studies related to PROTAC synthesis.

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Formel: C₁₇H₁₇N₃O₂
Molecular Weight:295.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6 ligand-4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HDAC6

Alle HDAC Isoform-spezifische Produkte anzeigen :

In Vitro

HDAC6 ligand-4 acts as a target protein ligand for TO-1187 (HY-173266), a selective HDAC6 PROTAC degrader (DC₅₀= 5.81 nM). TO-1187 promotes the ubiquitination and degradation of HDAC6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 295.34
Formel C₁₇H₁₇N₃O₂
SMILES

O=C(C1=CC=C(C=C1)CN(CC2=CN=CC=C2)CC#C)NO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Garcha H K, et al. Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability. Journal of Medicinal Chemistry. 2025;68(6):6165-6177.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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HDAC6 ligand-4

Alle HDAC Isoform-spezifische Produkte anzeigen