IHCH-3064
IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent.
For research use only. We do not sell to patients.
- CAS No.: 2420562-65-6
- Formula: C25H21N9O2
- Molecular Weight:479.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Adenosine Receptor Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | GI50 |
6.1 μM
Compound: 24e
|
Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 assay
Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 assay
|
[PMID: 34783558] |
| MC-38 | GI50 |
6.2 μM
Compound: 24e
|
Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 assay
Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 assay
|
[PMID: 34783558] |
Chemical Information
-
CAS No. 2420562-65-6
-
Molecular Weight 479.49
-
Formula C25H21N9O2
-
SMILES
O=C(C1=CC=C(CCN2N=CC3=C2N=C(N)N4N=C(C5=CC=CO5)N=C34)C=C1)NC6=C(N)C=CC=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)