f-MKKFRW
f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact.
For research use only. We do not sell to patients.
- Formula: C44H66N12O8S
- Molecular Weight:923.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6N (B6) mice (male, 8-14 weeks old); ΔFpr3-lacZ +/+ mice; cGao +/- mice; Trpc2 +/- mice[1]
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Dosage:50 μM; 100 μM
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Administration:topical application to filter paper; single exposure
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Result:Induced a mean avoidance index of -0.34 in B6 mice, indicating significant avoidance of the peptide-supplemented FEU compared to plain FEU. Showed absent avoidance in ΔFpr3-lacZ -/-, cGao -/-, and Trpc2 -/- mice.
Triggered avoidance behavior at the 50 μM dose.
Chemical Information
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Molecular Weight 923.14
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Formula C44H66N12O8S
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Sequence
{fMet}-Lys-Lys-Phe-Arg-Trp
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Sequence Shortening
{fMet}-MKKFRW
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
f-MKKFRW Related Classifications
HY-P11704 Related Classifications
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