オキソリン酸
Based on 3 publication(s) in Google Scholar
Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.97%
- CAS 番号: 14698-29-4
- 分子式: C13H11NO5
- 分子量:261.23
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Anti-Aging Compound Library
HY-L034
-
Antibacterial Compound Library
HY-L049
-
Antibiotics Library
HY-L067
-
Human Metabolite Library
HY-L123
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
MedChemExpress（MCE）の使用を引用している文献 Oxolinic acid
MoreAntibiotic アイソフォーム固有の製品をすべて表示
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
More
生物活性
Antimicrobial[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.81 μM
Compound: 1
|
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs
|
[PMID: 31299492] |
Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli[1].
Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis [1].
Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis[1].
Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747[2].
Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Swiss albino CD1 mice (22-25 g)[3]
-
Dosage:16 mg/kg, 32 mg/kg, 64 mg/kg, 128 mg/kg
-
Administration:Intraperitoneal injection
-
Result:Stimulated the horizontal activity of mice, culminated at the 32 mg/kg dose but disappeared at the highest tested dose, 128 mg/kg.
化学情報
-
CAS 番号 14698-29-4
-
性状 Solid
-
分子量 261.23
-
分子式 C13H11NO5
-
Color White to off-white
-
SMILES
O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O
-
別名
Oxolinic acid
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
J Xenobiot
Uses of Antibiotics in Ornamental Fish in Hong Kong and the Antibiotic Resistance in the Associated Zoonotic Pathogens. [Abstract]2022 Dec 4;12(4):365-377. PMID: 36547470 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
溶剤 & 溶解度
0.5 M NaOH : ≥ 50 mg/mL (191.40 mM)
DMSO : 1 mg/mL (3.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. M J Kershaw, et al. The antibacterial and pharmacological activity of oxolinic acid (Prodoxol). J Antimicrob Chemother. 1975 Sep;1(3):311-5. [Content Brief]
[2]. S H Manes, et al. Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling. J Bacteriol. 1983 Jul; 155(1): 420-423. [Content Brief]
[3]. J Garcia de Mateos-Verchere, et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8(4):255-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 0.5 M NaOH | 1 mM | 3.8280 mL | 19.1402 mL | 38.2804 mL | 95.7011 mL |
| 0.5 M NaOH | 5 mM | 0.7656 mL | 3.8280 mL | 7.6561 mL | 19.1402 mL |
| 10 mM | 0.3828 mL | 1.9140 mL | 3.8280 mL | 9.5701 mL | |
| 15 mM | 0.2552 mL | 1.2760 mL | 2.5520 mL | 6.3801 mL | |
| 20 mM | 0.1914 mL | 0.9570 mL | 1.9140 mL | 4.7851 mL | |
| 25 mM | 0.1531 mL | 0.7656 mL | 1.5312 mL | 3.8280 mL | |
| 30 mM | 0.1276 mL | 0.6380 mL | 1.2760 mL | 3.1900 mL | |
| 40 mM | 0.0957 mL | 0.4785 mL | 0.9570 mL | 2.3925 mL | |
| 50 mM | 0.0766 mL | 0.3828 mL | 0.7656 mL | 1.9140 mL | |
| 60 mM | 0.0638 mL | 0.3190 mL | 0.6380 mL | 1.5950 mL | |
| 80 mM | 0.0479 mL | 0.2393 mL | 0.4785 mL | 1.1963 mL | |
| 100 mM | 0.0383 mL | 0.1914 mL | 0.3828 mL | 0.9570 mL |
Oxolinic acid 関連分類
HY-B1002 関連分類
Powered by Bioz