country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187195

Copy Link Print Information

Abd141

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia.
(Pink: AURKA and ATR ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₄₃H₄₄N₈O₇S
分子量:816.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Abd141 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Abd141 is a dual PROTAC degrader of ATR and Aurora kinase A (AURKA), with DC₅₀ values of 97.7 nM and 6.7 nM, respectively. Abd141 inhibits the proliferation of acute lymphoblastic leukemia cells. Abd141 can be used in the research of acute lymphoblastic leukemia^[1]. (Pink: AURKA and ATR ligand (HY-187196); Blue: Cereblon ligand (HY-43722); Black: linker).

IC₅₀ & Target

^[1]

Aurora A

6.7 nM (DC₅₀)

ATR

97.7 nM (DC₅₀)

Cereblon

97 nM (Kd)

PROTACs アイソフォーム固有の製品をすべて表示 :

ATM/ATR アイソフォーム固有の製品をすべて表示 :

Aurora Kinase アイソフォーム固有の製品をすべて表示 :

体外実験

OthersAnti-cancerApoptosis

Others

Abd141 binds to CRBNmidi, with a measured K_d value of 97 nM determined by MST at 25 °C^[1].

Anti-cancer

Abd141 (10 nM-5 μM; 24 h) potently degrades ATR (DC₅₀ = 97.7 nM) and Aurora A (DC₅₀ = 6.7 nM) after 24-hour incubation in MOLT-4 acute lymphoblastic leukemia cells, and does not affect the level of WEE1 at a concentration of 500 nM^[1].
Abd141 (0.5 μM; 24-120 h) inhibits the proliferation of MOLT-4 acute lymphoblastic leukemia cells in a CRBN-dependent manner^[1].

Anti-cancer

Apoptosis

Abd141 (0.5 μM; 24 h) enhances Cytarabine (HY-13605)-induced apoptosis of MOLT-4 acute lymphoblastic leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MOLT-4 wild-type and MOLT-4ΔCRBN cells
Concentration:

0.5 μM
Incubation Time:

24 h, 96 h, 120 h
Result:

Stalled MOLT-4 wild-type cell growth, with significantly lower cell numbers at 96 h and 120 h compared to untreated controls.
Showed no growth suppression in MOLT-4ΔCRBN cells.

Apoptosis Analysis^[1]

Cell Line:

MOLT-4 cells
Concentration:

0.5 μM Abd141; 0.5 μM Cytarabine
Incubation Time:

24 h
Result:

Did not induce significant apoptosis when used alone.
Augmented Cytarabine-induced apoptosis from 34% to 62%.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

化学情報

分子量 816.92
分子式 C₄₃H₄₄N₈O₇S
SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCC3CCN(C(CCCC#CC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC3)=O)C=C2)=CN=C1N)NC7=CC=CC=C7
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Alfayomy AM, et al. Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells. European journal of medicinal chemistry. 2026 Jul 10;318:119125. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Abd141

PROTACs アイソフォーム固有の製品をすべて表示

ATM/ATR アイソフォーム固有の製品をすべて表示

Aurora Kinase アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Abd141 関連分類

HY-187195 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target