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製品番号: HY-W931056

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AMG-628

AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca²⁺ influx into TRPV1- expressing CHO cell with IC₅₀ of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats.

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CAS 番号: 862269-93-0
分子式: C₂₅H₂₅FN₆O₂S
分子量:492.57

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AMG-628 構造式

CAS 番号: 862269-93-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TRP Channel アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	2 nM Compound: 16p, AMG-628	Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx	[PMID: 17585751]
CHO	IC₅₀	3.7 nM Compound: 16p, AMG-628	Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx	[PMID: 17585751]

化学情報

CAS 番号 862269-93-0
分子量 492.57
分子式 C₂₅H₂₅FN₆O₂S
SMILES

CC(NC1=NC2=C(OC3=NC=NC(N4CCN([C@@H](C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50(15):3528-39. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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