Brevetoxin B
Based on 1 Customer Validation
Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and calcium currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.0%
- CAS 番号: 79580-28-2
- 分子式: C50H70O14
- 分子量:895.08
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
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| C6 | EC50 |
13 μM
Compound: BTXB
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Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
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[PMID: 22560474] |
Brevetoxin-B (0.011-1.11 μM; 10 min) concentration-dependently modulates multiple presynaptic ion currents at motor nerve terminals in mouse sternal deltoid muscle preparations: at a concentration of 0.11 μM, it enhances sodium and potassium currents while inhibiting calcium-activated potassium currents and slow calcium currents; at a concentration of 1.11 μM, it inhibits all detected ion currents[1].
Brevetoxin B (0-10 μg/mL; 0-48 h) affects the viability of Jurkat cells, causing a significant concentration- and time-dependent decrease in cellular metabolic activity[2].
Brevetoxin B (0-10 μg/mL; 3 h) significantly induces caspase-3-dependent apoptosis in Jurkat cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat
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Concentration:0, 2, 4, 6, 8 and 10 μg/mL
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Incubation Time:3, 24, 48 h
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Result:Remained greater than 94% at all tested concentrations with no significant decrease compared to controls after 3 h.
Significantly decreased compared to controls at concentrations of 1.25 μg/mL or greater after 24 h.
Dropped to less than 30% at all tested concentrations after 48 h.
化学情報
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CAS 番号 79580-28-2
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性状 Solid
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分子量 895.08
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分子式 C50H70O14
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Color White to off-white
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SMILES
C[C@@]1(O[C@](C)(CC[C@@](O[C@@](C[C@](C)(O[C@@](C(C)=CC2=O)([H])[C@](O2)([H])C3)[C@]3([H])O4)([H])[C@]4([H])C5)([H])[C@]([C@@H]5C)([H])O6)[C@]6([H])C7)[C@]7([H])O[C@]8(C)[C@@](O[C@](C[C@](O[C@@](C)([C@H]9O)[C@@](O[C@H](CC(C=O)=C)C9)([H])C%10)([H])[C@@]%10([H])O%11)([H])[C@@]%11([H])/C=C\C8)([H])C1
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別名
Brevetoxin-2; PbTx-2
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tsai MC, et al. Effects of brevetoxin-B on motor nerve terminals of mouse skeletal muscle. Br J Pharmacol. 1991;103(1):1126-1128. [Content Brief]
[2]. Walsh CJ, et al. Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat). Mar Drugs. 2008;6(2):291-307. Published 2008 Jun 10. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Brevetoxin B 関連分類
HY-12546 関連分類
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