Chrysosplenol C
Chrysosplenol C is a type of flavonoid compound. Chrysosplenol C selectively activates cardiac myosin ATPase, with its EC50 being 45 µM. Chrysosplenol C enhances the release of intracellular calcium ions by activating protein kinase C (PKC), thereby increasing the contractility of rat ventricular muscle cells. Chrysosplenol C can be used in the research of heart failure.
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- CAS 番号: 23370-16-3
- 分子式: C18H16O8
- 分子量:360.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | ED50 |
11.2 μg/mL
Compound: chrysosplenol C
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Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
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[PMID: 1955888] |
化学情報
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CAS 番号 23370-16-3
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分子量 360.31
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分子式 C18H16O8
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SMILES
O=C1C(OC)=C(C2=CC(OC)=C(O)C=C2)OC3=CC(OC)=C(C(O)=C13)O
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Venkateswararao E, et al. Exploration of Pharmacophore in Chrysosplenol C as Activator in Ventricular Myocyte Contraction. ACS Med Chem Lett. 2015 May 20;6(7):758-63. [Content Brief]
[2]. Wang J, et al. Chrysosplenol-C Increases Contraction by Augmentation of Sarcoplasmic Reticulum Ca2+ Loading and Release via Protein Kinase C in Rat Ventricular Myocytes. Mol Pharmacol. 2022 Jan;101(1):13-23. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Chrysosplenol C 関連分類
HY-N13747 関連分類
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