Formycin A
Based on 1 Customer Validation
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 6742-12-7
- 分子式: C10H13N5O4
- 分子量:267.24
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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HIV-1 10 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
1 μM
Compound: formycin A
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Cytotoxic concentration required to reduce rate of L1210 cell proliferation after 48 hr
Cytotoxic concentration required to reduce rate of L1210 cell proliferation after 48 hr
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[PMID: 4068000] |
| MDCK | CC50 |
2.6 μM
Compound: 7; FMA
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Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter96 Aqueous one solution assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter96 Aqueous one solution assay
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[PMID: 35092894] |
| S49 | IC50 |
9.3 μM
Compound: 1
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Compound evaluated for the inhibitory concentration of S49 Mouse Lymphoma T-cells
Compound evaluated for the inhibitory concentration of S49 Mouse Lymphoma T-cells
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[PMID: 3874961] |
Formycin A (NSC 102811; 1 μM, 5 μM, 10 μM) antagonizes Zidovudine (AZT; a dideoxynucleoside chain terminator).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 6742-12-7
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性状 Solid
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分子量 267.24
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分子式 C10H13N5O4
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NNC3=C2N=CN=C3N
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別名
NSC 102811; ホルマイシンA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63. [Content Brief]
[2]. Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Formycin A 関連分類
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