LAG3 - lymphocyte activating 3 Gene

Also Known as CD223

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3902

About LAG3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,772,520-6,778,455 (from NCBI)

This gene has 4 transcripts (splice variants), 103 orthologues and 10 paralogues. Biased expression in spleen (RPKM 15.1), lymph node (RPKM 8.3) and 12 other tissues.

Summary

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

LAG3 Products (3)

mRNA Protein Name
NM_001414176.1 NP_001401105.1 lymphocyte activation gene 3 protein isoform 2 precursor
NM_001414177.1 NP_001401106.1 lymphocyte activation gene 3 protein isoform 3 precursor
NM_002286.6 NP_002277.4 lymphocyte activation gene 3 protein isoform 1 precursor

LAG3 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (174 - 259)

Ig_2

Ig_2: Immunoglobulin domain (270 - 347)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

lymphocyte activation gene 3 protein

  • lymphocyte-activation gene 3

LAG3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Cross
LAG3 P18627 Fgl1 Mus musculus Q71KU9
Array
30580966
Intra
LAG3 P18627 FGL1 Homo sapiens Q08830
Array
30580966
Intra
LAG3 P18627 FGL1 Homo sapiens Q08830
BLI
30580966
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAG3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70723 LAG-3 Protein, Human (HEK293, Fc) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70735 LAG-3 Protein, Human (HEK293, mFc) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70722 LAG-3 Protein, Human (HEK293, His) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72389 LAG-3 Protein, Human (Biotinylated, HEK293, His-Avi) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78846 LAG-3 Protein, Human (Biotinylated, HEK293, mFc-Avi) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78847 LAG-3 Protein, Human (Biotinylated, HEK293, Fc-Avi) P18627-1 (L23-L450) ≥ 95%, as determined by reducing SDS-PAGE.

LAG3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81716 CD223/LAG-3 Antibody (YA1461) FC, ELISA Human
HY-P84145 CD223/LAG-3 Antibody (YA3842) WB, FC, ELISA Human
HY-P84145A CD223/LAG-3 Antibody (YA3842)(PBS only) WB, FC, ELISA Human
HY-P84976 CD223/LAG-3 Antibody (YA4668) ELISA Human
HY-P86937 CD223/LAG-3 Antibody (YA6630) WB, ICC/IF Mouse

関連疾患

Diseases Alias
Kyphoscoliotic Heart Disease
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Endocervical Carcinoma

  • Carcinoma Of Endocervix

  • Carcinoma Of The Endocervix
Uterine Body Mixed Cancer

  • Malignant Mixed Tumor Of Corpus Uteri

  • Malignant Mixed Tumor, Not Otherwise Specified
Endocervical Adenocarcinoma

  • Endocervical Carcinoma
Uterine Corpus Cancer

  • Corpus Uteri Cancer

  • Malignant Uterine Corpus Neoplasm
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

阻害性抗体 (15)
製品番号 製品名 製品効果
純度 Phase
HY-P99156 Relatlimab 98.00% Phase 4
HY-P99573 Tebotelimab 99.52% Phase 3
HY-P99613 Favezelimab 97.79% Phase 3
HY-P99617 Fianlimab 99.04% Phase 3
HY-P990968 Alcestobart 98.383% Phase 3
HY-P99027 Ieramilimab ≥99.0% Phase 2
HY-P990750 Negalstobart 96.89% Phase 2
HY-P990700 Tobemstomig 97.06% Phase 2
HY-P99736 Miptenalimab 97.04% Phase 2
HY-P990046 Tuparstobart 97.65% Phase 2
HY-P990740 Fanastomig 95.478% Phase 2
HY-P991300 GSK2831781 Inhibitor / Phase 2
HY-P991605 HLX26 Inhibitor / Phase 2
HY-P991301 IMP-761 Inhibitor 97.24% Phase 1
HY-P991303 TQB-2223 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-144088 ZYF0033 Inhibitor 98.82% Unkown
HY-172930 PVTX-405 / Unkown
HY-176813 LAG-3 Hit II Inhibitor 99.58% Unkown
HY-162811 LAG-3 biner 1 97.08% Unkown
HY-164308 SA-15-P Inhibitor 99.62% Unkown
HY-122081 CPI-644 Inhibitor / Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-149916 A2AR-antagonist-1 Antagonist 96.68% Unkown
HY-176814 LAG-3-IN-1 Inhibitor / Unkown
HY-178320 LAG-3-IN-2 Inhibitor / Unkown
HY-179060 LAG-3 PROTAC-1 Degrader / Unkown
HY-179061 LAG-3 degrader 1 Degrader / Unkown
HY-179071 DAPK1 ligand-1 Degrader / Unkown
HY-180900 Z3071585108 Ligand / Unkown
HY-181685 LAGi-DEL Inhibitor / Unkown
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / Unkown
HY-P10837 LAG-3 cyclic peptide inhibitor 12 Inhibitor / Unkown
HY-RS07492 LAG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16686 Lag3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23121 Lag3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (15)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P99141 Anti-Mouse LAG-3 Antibody (C9B7W) Inhibitor 99% Unkown
HY-P99922 Encelimab Inhibitor 95.25% Unkown
HY-P990976 Brivestobart 99.198% Unkown
HY-P990912 Cugrastomig 98.46% Unkown
HY-P99354 Bavunalimab 99.408% Unkown
HY-P991297 AM0003 Inhibitor / Unkown
HY-P991298 DNV-3 Inhibitor / Unkown
HY-P991299 ENUM006 Inhibitor / Unkown
HY-P991302 KL-A289 Inhibitor / Unkown
HY-P992075 Anti-Bovine LAG-3 Antibody (2D8) Inhibitor / Unkown
HY-P992254 Anti-LAG-3 Antibody (BAP050) Inhibitor / Unkown
HY-P992352 ES005 / Unkown
HY-P992461 SHR-1802 Inhibitor / Unkown
HY-P990204 Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) Inhibitor / Unkown
HY-P992156 Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris LAG3 VGNC VGNC:42562
Macaca mulatta LAG3 VGNC VGNC:108356
Felis catus LAG3 VGNC VGNC:68001
Rattus norvegicus LAG3 RGD RGD:1302990
Bos taurus LAG3 VGNC VGNC:30767
Mus musculus LAG3 MGD MGI:106588
Others LAG3 NCBI