MTAP - methylthioadenosine phosphorylase Gene

Also Known as BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4507

About MTAP

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,802,636-21,941,115 (from NCBI)

This gene has 13 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 5.5), esophagus (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]

MTAP Products (7)

mRNA	Protein	Name
NM_001396040.1	NP_001382969.1	S-methyl-5'-thioadenosine phosphorylase isoform 2
NM_001396041.1	NP_001382970.1	S-methyl-5'-thioadenosine phosphorylase isoform 3
NM_001396042.1	NP_001382971.1	S-methyl-5'-thioadenosine phosphorylase isoform 4
NM_001396043.1	NP_001382972.1	S-methyl-5'-thioadenosine phosphorylase isoform 5
NM_001396044.1	NP_001382973.1	S-methyl-5'-thioadenosine phosphorylase isoform 6
NM_001396045.1	NP_001382974.1	S-methyl-5'-thioadenosine phosphorylase isoform 7
NM_002451.4	NP_002442.2	S-methyl-5'-thioadenosine phosphorylase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
NOT involved in nicotinamide riboside catabolic process	IDA IDA: Inferred from direct assay	19001417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTAP Protein Structure

PNP_UDP_1

0
100
200
283 a.a.

Protein Preferred Names	Protein Names
S-methyl-5'-thioadenosine phosphorylase	5'-methylthioadenosine phosphorylase

MTAP Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MTAP	Q13126	CENPH	Homo sapiens	Q9H3R5	Y2H Array	25416956
Intra	MTAP	Q13126	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	25416956
Intra	MTAP	Q13126	EMC3	Homo sapiens	Q9P0I2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MTAP 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83340	MTAP Antibody (YA3085)	WB	Human, Mouse
HY-P83340A	MTAP Antibody (YA3085)(PBS only)	WB	Human, Mouse

関連疾患

Diseases	Alias
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma	DMSMFH Bone Dysplasia With Medullary Fibrosarcoma Bdmf Bone Dysplasia With Malignant Fibrous Histiocytoma Hardcastle Syndrome Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome Myopathy, Limb-Girdle, With Bone Fragility Bone Dysplasia-Medullary Fibrosarcoma Syndrome Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome Dms-Mfh Limb-Girdle Myopathy With Bone Fragility Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Bone Sarcoma
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Biliary Tract Cancer	Malignant Tumour Of Biliary Tract Biliary Tract Neoplasms Biliary Tract Neoplasm
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Peritoneal Mesothelioma	Malignant Mesothelioma Of Peritoneum Advanced Malignant Mesothelioma Of Peritoneum Advanced Malignant Peritoneal Mesothelioma Advanced Peritoneal Malignant Mesothelioma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Pleural Cancer	Pleural Neoplasms Neoplasm Of Pleura Pleural Tumor Malignant Tumor Of Pleura Pleural Cavity Cancer Primary Malignant Neoplasm Of Parietal Pleura Primary Malignant Neoplasm Of Pleura Primary Malignant Neoplasm Of Visceral Pleura
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Phase
HY-156680	Vopimetostat	Inhibitor	99.55%	Phase 2
HY-148419	Ralometostat	Inhibitor	99.90%	Phase 2
HY-16933	L-Alanosine	Inhibitor	99.85%	Phase 2

Pre-clinical Phase

Bioactive Molecules (44)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-153390	AMG-193	Inhibitor	99.71%	Unkown
HY-101496	MT-DADMe-ImmA	Inhibitor	99.17%	Unkown
HY-112130	AGI-24512	Inhibitor	99.46%	Unkown
HY-145778	AGI-41998	Inhibitor	98.72%	Unkown
HY-162353	AZ'9567		99.19%	Unkown
HY-145777	AGI-43192	Inhibitor	99.47%	Unkown
HY-138684	MRTX9768	Inhibitor	99.60%	Unkown
HY-153390A	(R)-AMG-193	Inhibitor	98.53%	Unkown
HY-158143	AZD3470		99.74%	Unkown
HY-162783	AZ-PRMT5i-1	Inhibitor	/	Unkown
HY-138684A	MRTX9768 hydrochloride	Inhibitor	99.88%	Unkown
HY-112129	AGI25696-analog		/	Unkown
HY-142928	MAT2A-IN-1	Inhibitor	/	Unkown
HY-142929	MAT2A-IN-2	Inhibitor	/	Unkown
HY-142930	MAT2A-IN-3	Inhibitor	/	Unkown
HY-144181	MAT2A-IN-5	Inhibitor	/	Unkown
HY-144184	MAT2A-IN-6	Inhibitor	/	Unkown
HY-144185	MAT2A-IN-7	Inhibitor	/	Unkown
HY-155149	MAT2A-IN-12	Inhibitor	/	Unkown
HY-162010	MAT2A-IN-13	Inhibitor	/	Unkown
HY-163799	PRMT5-MTA-IN-1	Inhibitor	/	Unkown
HY-168445	MAT2A-IN-21	Inhibitor	/	Unkown
HY-170421	MAT2A-IN-16	Inhibitor	/	Unkown
HY-170905S	MAT2A-IN-22	Inhibitor	/	Unkown
HY-170906S	MAT2A-IN-23	Inhibitor	/	Unkown
HY-172733	PRMT5-MTA-IN-3	Inhibitor	/	Unkown
HY-172733S	PRMT5-MTA-IN-3-d3	Inhibitor	/	Unkown
HY-173281	MAT2A-IN-24	Inhibitor	/	Unkown
HY-174983	PRMT5-MTA-IN-6	Inhibitor	/	Unkown
HY-176702	PRMT5-MTA-IN-5	Inhibitor	/	Unkown
HY-179622	ZS34		/	Unkown
HY-180816	PRMT5-MTA-IN-7	Inhibitor	/	Unkown
HY-180918	ERG-IN-4		/	Unkown
HY-180919	ERG-IN-5	Inhibitor	/	Unkown
HY-181260	PRMT5-MTA-IN-8		/	Unkown
HY-182400	AGI-25696	Inhibitor	/	Unkown
HY-183568	MAT2A-IN-26	Inhibitor	/	Unkown
HY-183951	TNG456	Inhibitor	/	Unkown
HY-184290	PRMT5-IN-56		/	Unkown
HY-184434	PRMT5-IN-57	Inhibitor	/	Unkown
HY-RS08749	MTAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W750643	m-APTA	Substrate	99.54%	Unkown
HY-RS16680	Mtap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23115	Mtap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	MTAP	RGD	RGD:1310114
Felis catus	MTAP	VGNC	VGNC:102952
Macaca mulatta	MTAP	VGNC	VGNC:103835
Canis familiaris	MTAP	VGNC	VGNC:56069
Mus musculus	MTAP	MGD	MGI:1914152
Others	MTAP	NCBI