Grossamide
Based on 1 publication(s) in Google Scholar
Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 80510-06-1
- 分子式: C36H36N2O8
- 分子量:624.68
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Grossamide
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生物活性
Grossamide downregulates LPS-mediated production of inflammatory molecules[1].
Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h and co-cultured with LPS (100 ng/mL) for another 6 h
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Result:Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h
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Result:Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h
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Result:Had no cytotoxicity.
化学情報
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CAS 番号 80510-06-1
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性状 Solid
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分子量 624.68
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分子式 C36H36N2O8
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Color White to off-white
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SMILES
O=C([C@H]1C2=CC(/C=C/C(NCCC(C=C3)=CC=C3O)=O)=CC(OC)=C2O[C@]1([H])C(C=C4)=CC(OC)=C4O)NCCC(C=C5)=CC=C5O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Comput Aided Mol Des
Integrated computational and experimental evaluation of grossamide as a natural product scaffold for dual carbohydrase inhibition in diabetes. [Abstract]2025 Nov 10;39(2):122. PMID: 41212441
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Grossamide 関連分類
HY-N3979 関連分類
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