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製品番号: HY-186172

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KS0365

KS0365 is a selective TRPV3 agonist with an EC₅₀ of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca²⁺]_i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing.

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CAS 番号: 1689577-22-7
分子式: C₁₅H₁₉ClO
分子量:250.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

KS0365 構造式

CAS 番号: 1689577-22-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

TRPV3

5.08 μM (EC₅₀)

TRP Channel アイソフォーム固有の製品をすべて表示 :

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

KS0365 (0.1-100 μM; 20 μM primary screen; 10 μM validation) potently and selectively activates recombinant mouse TRPV3 in HEK_mTRPV3-CFP cells with an EC₅₀ of 5.08 μM, inducing sustained [Ca²⁺]ᵢ increases without significant off-target effects at 10 μM^[1].
KS0365 (0.8-12.5 μM HEK cells; 10-50 μM m308k cells; 24 h) induces TRPV3-dependent metabolic activity changes: it reduces metabolic activity in TRPV3-overexpressing HEK_mTRPV3-CFP cells and causes a biphasic effect in m308k Mus musculus keratinocytes, with a TRPV3-mediated increase at 10 μM and off-target toxicity at 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK_mTRPV3-CFP cells, parental HEK293 cells, m308k mouse keratinocytes
Concentration:

0.8-12.5 μM (HEK cells); 10-50 μM (m308k cells)
Incubation Time:

24 h
Result:

Caused a concentration-dependent decrease in metabolic activity in HEK_mTRPV3-CFP cells, which was reversed by co-treatment with 10 μM ruthenium red.
Showed no decrease in metabolic activity in parental HEK293 cells.
Exhibited a biphasic effect in m308k cells: 10 μM and 25 μM slightly but significantly increased metabolic activity (126.5% and 107.8% of untreated control, respectively), while 50 μM drastically decreased metabolic activity.
Inhibited the pro-metabolic effect of 10 μM KS0365 by 10 μM ruthenium red, but effects of 25 μM and 50 μM KS0365 were unaffected by ruthenium red.

化学情報

CAS 番号 1689577-22-7
分子量 250.76
分子式 C₁₅H₁₉ClO
SMILES

ClC1=C(C(C)C)CCC1C2=CC(C)=CC=C2O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Maier M, et al. KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration. Br J Pharmacol. 2022;179(24):5290-5304. [Content Brief]

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分子量分子量

希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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KS0365

TRP Channel アイソフォーム固有の製品をすべて表示

Calcium Channel アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

KS0365 関連分類

HY-186172 関連分類