Olvanil
Based on 1 Customer Validation
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 58493-49-5
- 分子式: C26H43NO3
- 分子量:417.62
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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TRPV1 0.7 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
202 nM
Compound: 24
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Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake
Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake
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[PMID: 22796184] |
| DMS-114 | IC50 |
>50 μM
Compound: 5
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Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| EFM-19 | IC50 |
0.7 μM
Compound: 5
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Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| MCF7 | IC50 |
1 μM
Compound: 5
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Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| T47D | IC50 |
0.75 μM
Compound: 5
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Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
Olvanil affects C6 glioma cell proliferation (IC50 value of 5.5 μM)[2]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats weighing approximately 200 g[3]
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Dosage:0, 0.2, 1.0 and 5.0 mg/kg
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Administration:Injected intraperitoneally 30 min before the behavioral tests
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Result:The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 58493-49-5
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性状 Solid
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分子量 417.62
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分子式 C26H43NO3
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
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別名
NE-19550; N-Vanillyloleamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
DMSO : 100 mg/mL (239.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Giovanni Appendino, et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther. 2005 Feb;312(2):561-70. [Content Brief]
[2]. S O Jacobsson, et al. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.J Pharmacol Exp Ther. 2001 Dec;299(3):951-9. [Content Brief]
[3]. John W Kasckow, et al. Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):291-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3945 mL | 11.9726 mL | 23.9452 mL | 59.8630 mL |
| 5 mM | 0.4789 mL | 2.3945 mL | 4.7890 mL | 11.9726 mL | |
| 10 mM | 0.2395 mL | 1.1973 mL | 2.3945 mL | 5.9863 mL | |
| 15 mM | 0.1596 mL | 0.7982 mL | 1.5963 mL | 3.9909 mL | |
| 20 mM | 0.1197 mL | 0.5986 mL | 1.1973 mL | 2.9932 mL | |
| 25 mM | 0.0958 mL | 0.4789 mL | 0.9578 mL | 2.3945 mL | |
| 30 mM | 0.0798 mL | 0.3991 mL | 0.7982 mL | 1.9954 mL | |
| 40 mM | 0.0599 mL | 0.2993 mL | 0.5986 mL | 1.4966 mL | |
| 50 mM | 0.0479 mL | 0.2395 mL | 0.4789 mL | 1.1973 mL | |
| 60 mM | 0.0399 mL | 0.1995 mL | 0.3991 mL | 0.9977 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2993 mL | 0.7483 mL | |
| 100 mM | 0.0239 mL | 0.1197 mL | 0.2395 mL | 0.5986 mL |
Olvanil 関連分類
HY-101323 関連分類
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