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製品番号: HY-145266

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OM-1700

OM-1700 is a potent tankyrase inhibitor with IC₅₀s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI₅₀=650 nM).

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CAS 番号: 2406276-78-4
分子式: C₂₅H₂₃FN₆O₂
分子量:458.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

OM-1700 構造式

CAS 番号: 2406276-78-4

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

TNKS1

127 nM (IC₅₀)

TNKS2

14 nM (IC₅₀)

PARP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 320DM	GI₅₀	650 nM Compound: 13; OM-1700	Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay Antiproliferative activity against human COLO320DM cells measured after 5 days by MTS assay	[PMID: 32511917]
COLO 320DM	GI₅₀	650 nM Compound: 1; OM-1700	Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay Antiproliferative activity against human COLO 320DM cells assessed as growth inhibition incubated for 5 days by MTS assay	[PMID: 34878777]
HEK293	IC₅₀	19 nM Compound: 13; OM-1700	Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo luciferase reporter gene assay	[PMID: 32511917]
RKO	GI₅₀	>10000 nM Compound: 1; OM-1700	Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay Antiproliferative activity against human RKO cells assessed as growth inhibition incubated for 5 days by MTS assay	[PMID: 34878777]

体外実験

OM-153 shows inhibition (IC₅₀=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2406276-78-4
分子量 458.49
分子式 C₂₅H₂₃FN₆O₂
SMILES

FC1=[C@](C=CC=C1)[N@]2C([C@]3([H])C[C@H](C3)NC(C4=CC=CC=N4)=O)=NN=C2C5=CC=C(C=N5)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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OM-1700

PARP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

OM-1700 関連分類

HY-145266 関連分類