Phleomycin
Based on 2 publication(s) in Google Scholar
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research.
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- 純度: 95.0%
- CAS 番号: 11006-33-0
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Phleomycin
MoreAntibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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Glycopeptide |
1. Phleomycin (1-25 μg/mL; overnight) can increase the transformation efficiency by more than 10 times in the protoplast transformation experiment of Schizophyllum commune, promote single copy integration, and upregulate the expression of DNA repair genes KU70 and RAD52[2].
2. Phleomycin (2 μg/mL, 10 μg/mL; 90 min-4 h) selectively inhibits DNA synthesis in Escherichia coli (E. coli) and HeLa cells and reduces 3H-thymidine incorporation into DNA. At 20 μg/mL, the DNA degradation activity is significantly lower than that of Mitomycin C (HY-13316)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 11006-33-0
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性状 Solid
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Color Light blue to blue
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SMILES
[Phleomycin]
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Structure Classification
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Initial Source
Streptoalloteichus hindustanus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
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Journal Impact Factor
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Most Recent
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FEMS Yeast Res
Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression. [Abstract]2025 May 22:foaf027. PMID: 40402811 -
Genes Cells
SRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe. [Abstract]2025 Jan;30(1):e13192. PMID: 39789818
溶剤 & 溶解度
H2O : 100 mg/mL (Need ultrasonic)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kamila Stokowa-Sołtys, et al. Phleomycin complex-Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82. [Content Brief]
[2]. van Peer AF, et al. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75(5):1243-7. [Content Brief]
[3]. TANAKA N, et al. Mechanism of action of phleomycin, a tumor-inhibitory antibiotic. Biochem Biophys Res Commun. 1963 Jan 31;10:171-4. [Content Brief]
Calculators
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