PTERi
Based on 1 Customer Validation
PTERi is a selective inhibitor of PTER with selectivity towards HDACs. PTERi increases the level of N-acetyltaurine in both lean and obese mice, and reduces food intake in obese mice. PTERi can be used in the research of obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.04%
- CAS 番号: 3114432-21-9
- 分子式: C19H20N2O6
- 分子量:372.37
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
PTERi (Compound 41) (1 h) potently and selectively inhibits recombinant mouse PTER-mediated N-acetyltaurine hydrolysis, with over 250-fold selectivity over HDAC enzymes[1].
PTERi exhibits only weak inhibitory activity against HDACs 1-11 and SIRTs 1-4, and shows high selectivity for PTER[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male; diet-induced obese)[1]
-
Dosage:100 mg/kg (acute studies; 1 week; 3 weeks; 27 days; 10 days rebound study)
-
Administration:i.p.; daily (chronic/rebound/combination studies); single dose (acute studies)
-
Result:Induced a dose-dependent increase in plasma N-acetyltaurine levels in lean mice, and increased levels up to 1 hour post-injection in lean mice and 2 hours post-injection in obese mice.
Reduced food intake at 6 and 18 hours post-single injection in obese mice.
Decreased cumulative food intake and reduced body weight over 8 days and 3 weeks of daily treatment in obese mice.
Resulted in loss of adipose mass with no changes in liver, kidney, or heart mass after 27 days of daily treatment.
When combined with semaglutide, further reduced cumulative food intake and lowered body weight compared to vehicle-treated obese mice over 1 week.
Prevented weight regain in obese mice switched from semaglutide to PTER-IN-1 after 15 days of semaglutide treatment; these mice maintained weight loss at a level comparable to mice continuing semaglutide therapy, whereas mice switched to vehicle gained weight.
化学情報
-
CAS 番号 3114432-21-9
-
性状 Solid
-
分子量 372.37
-
分子式 C19H20N2O6
-
Color White to off-white
-
SMILES
O=C(CCOCCOCCN1C(C2=C3C(C1=O)=CC=CC3=CC=C2)=O)NO
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (67.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6855 mL | 13.4275 mL | 26.8550 mL | 67.1375 mL |
| 5 mM | 0.5371 mL | 2.6855 mL | 5.3710 mL | 13.4275 mL | |
| 10 mM | 0.2686 mL | 1.3428 mL | 2.6855 mL | 6.7138 mL | |
| 15 mM | 0.1790 mL | 0.8952 mL | 1.7903 mL | 4.4758 mL | |
| 20 mM | 0.1343 mL | 0.6714 mL | 1.3428 mL | 3.3569 mL | |
| 25 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6855 mL | |
| 30 mM | 0.0895 mL | 0.4476 mL | 0.8952 mL | 2.2379 mL | |
| 40 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6784 mL | |
| 50 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3428 mL | |
| 60 mM | 0.0448 mL | 0.2238 mL | 0.4476 mL | 1.1190 mL |
PTERi 関連分類
HY-185341 関連分類
Powered by Bioz